Tohen Mauricio, Frank Ellen, Bowden Charles L, Colom Francesc, Ghaemi S Nassir, Yatham Lakshmi N, Malhi Gin S, Calabrese Joseph R, Nolen Willem A, Vieta Eduard, Kapczinski Flávio, Goodwin Guy M, Suppes Trisha, Sachs Gary S, Chengappa Kn Roy, Grunze Heinz, Mitchell Philip B, Kanba Shigenobu, Berk Michael
Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7792, San Antonio, TX 78229, USA.
Bipolar Disord. 2009 Aug;11(5):453-73. doi: 10.1111/j.1399-5618.2009.00726.x.
Via an international panel of experts, this paper attempts to document, review, interpret, and propose operational definitions used to describe the course of bipolar disorders for worldwide use, and to disseminate consensus opinion, supported by the existing literature, in order to better predict course and treatment outcomes.
Under the auspices of the International Society for Bipolar Disorders, a task force was convened to examine, report, discuss, and integrate findings from the scientific literature related to observational and clinical trial studies in order to reach consensus and propose terminology describing course and outcome in bipolar disorders.
Consensus opinion was reached regarding the definition of nine terms (response, remission, recovery, relapse, recurrence, subsyndromal states, predominant polarity, switch, and functional outcome) commonly used to describe course and outcomes in bipolar disorders. Further studies are needed to validate the proposed definitions.
Determination and dissemination of a consensus nomenclature serve as the first step toward producing a validated and standardized system to define course and outcome in bipolar disorders in order to identify predictors of outcome and effects of treatment. The task force acknowledges that there is limited validity to the proposed terms, as for the most part they represent a consensus opinion. These definitions need to be validated in existing databases and in future studies, and the primary goals of the task force are to stimulate research on the validity of proposed concepts and further standardize the technical nomenclature.
通过一个国际专家小组，本文试图记录、回顾、解读并提出用于描述双相情感障碍病程以供全球使用的操作性定义，并传播现有文献支持的共识性意见，以便更好地预测病程和治疗结果。
在国际双相情感障碍协会的支持下，召集了一个特别工作组，以审查、报告、讨论并整合来自与观察性和临床试验研究相关的科学文献中的研究结果，从而达成共识并提出描述双相情感障碍病程和结果的术语。
就双相情感障碍病程和结果常用的九个术语（反应、缓解、康复、复发、再发、亚综合征状态、主要极性、转换和功能结果）的定义达成了共识性意见。需要进一步研究来验证所提出的定义。
确定并传播共识性命名法是朝着建立一个经过验证和标准化的系统迈出的第一步，该系统用于定义双相情感障碍的病程和结果，以便识别结果预测因素和治疗效果。特别工作组承认所提出的术语有效性有限，因为在很大程度上它们代表的是一种共识性意见。这些定义需要在现有数据库和未来研究中得到验证，特别工作组的主要目标是推动对所提出概念的有效性进行研究，并进一步规范技术命名法。
