Scherberich J E
Abteilung Nephrologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Bundesrepublik Deutschland.
Wien Klin Wochenschr Suppl. 1991;189:5-9.
The pathophysiological and pathobiochemical background of enzymuria in patients with renal involvement in discussed. Selected markers of the human nephron such as angiotensinase-A, aminopeptidase-M, L-gamma-glutamyl-transferase and dipeptidylpeptidase-IV are characterized; inductive as well as ischaemic/toxic events may induce increased shedding of membrane bound marker-enzymes. Pathological enzyme excretion profiles related to defined renal diseases indicate that tissue-proteinuria of renal origin is a potential noninvasive tool for diagnostic purposes.
本文讨论了肾脏受累患者酶尿的病理生理和病理生化背景。对人肾单位的一些特定标志物，如血管紧张素酶-A、氨肽酶-M、L-γ-谷氨酰转移酶和二肽基肽酶-IV进行了特征描述；诱导性以及缺血/毒性事件可能会导致膜结合标志物酶的脱落增加。与特定肾脏疾病相关的病理性酶排泄谱表明，源自肾脏的组织蛋白尿是一种潜在的用于诊断目的的非侵入性工具。
