Wang Hongbo, Gorpudolo Nowiah, Behr Barry
Department of OB/GYN, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Obstet Gynecol Surv. 2009 Aug;64(8):542-7. doi: 10.1097/OGX.0b013e3181ab5479.
This review will address the current understanding of the relationship between prolactin (PRL) and endometriosis-associated infertility. Although the exact mechanisms of action of hyperprolactinemia in patients with endometriosis-associated infertility have not been clearly established, this report reviews results from relevant studies in the literature. These include serum PRL levels in endometriosis-associated infertility, PRL receptors in ectopic endometriotic tissues, basal PRL levels after TSH and Danazol (isoxazolic derivative of the synthetic steroid 5alpha-ethinyl-testosterone) therapy, peritoneal fluid and nocturnal serum PRL levels in endometriosis, infertility, and luteal phase PRL concentrations in patients with endometriosis.
Obstetricians & Gynecologists, Family Physicians.
After completion of this article, the reader should be able to explain the relationship between prolactin- and endometriosis-associated infertility, relate endometriosis with infertility, and summarize two ways in which prolactin and endometriosis may be linked in the pathophysiology of infertility.
本综述将阐述目前对催乳素（PRL）与子宫内膜异位症相关性不孕之间关系的理解。尽管高催乳素血症在子宫内膜异位症相关性不孕患者中的确切作用机制尚未明确确立，但本报告回顾了文献中相关研究的结果。这些研究包括子宫内膜异位症相关性不孕患者的血清PRL水平、异位子宫内膜组织中的PRL受体、促甲状腺激素（TSH）和达那唑（合成类固醇5α-乙炔基睾酮的异恶唑衍生物）治疗后的基础PRL水平、子宫内膜异位症患者的腹腔液和夜间血清PRL水平、不孕情况以及黄体期PRL浓度。
妇产科医生、家庭医生。
阅读本文后，读者应能够解释催乳素与子宫内膜异位症相关性不孕之间的关系，阐述子宫内膜异位症与不孕的关联，并总结催乳素和子宫内膜异位症在不孕病理生理学中可能存在关联的两种方式。
