Machida T, Taga M, Minaguchi H
Department of Obstetrics and Gynecology, Yokohama City University, School of Medicine, Japan.
Eur J Obstet Gynecol Reprod Biol. 1997 Mar;72(1):89-92. doi: 10.1016/s0301-2115(96)02649-8.
To clarify a significance of prolactin (PRL) for infertility in endometriosis.
For seventy endometriotic patients with or without infertility, serum PRL concentrations measured by radioimmunoassay before and 30 min after 500 micrograms of thyrotropin-releasing hormone (TRH) injection were analyzed in relation to the Revised American Fertility Society score in endometriosis as well as to the outcome of the treatment for endometriotic infertility.
While no significant relationship was found between the basal PRL levels and the stage of endometriosis or the outcome of the treatment for infertility, the PRL value after TRH injection was significantly greater in the patients who did not become pregnant than those who did (P < 0.05).
Occult hyperprolactinemia may be involved in infertility in endometriotic patients.
阐明催乳素（PRL）在子宫内膜异位症所致不孕症中的意义。
针对70例患有或未患不孕症的子宫内膜异位症患者，分析通过放射免疫测定法在注射500微克促甲状腺激素释放激素（TRH）前及注射后30分钟测得的血清PRL浓度，这些浓度与子宫内膜异位症修订后的美国生育协会评分以及子宫内膜异位症不孕症的治疗结果相关。
虽然基础PRL水平与子宫内膜异位症分期或不孕症治疗结果之间未发现显著关系，但未怀孕患者注射TRH后的PRL值显著高于怀孕患者（P < 0.05）。
隐匿性高催乳素血症可能与子宫内膜异位症患者的不孕症有关。
