Muse K, Wilson E A, Jawad M J
Fertil Steril. 1982 Oct;38(4):419-22. doi: 10.1016/s0015-0282(16)46574-x.
In order to clarify the role of hyperprolactinemia as a possible cause of infertility in patients with endometriosis, baseline serum prolactin (PRL) concentrations and the PRL response to thyrotropin-releasing hormone (TRH) stimulation were measured in 14 infertile women with endometriosis and in 13 normal, fertile women. Baseline PRL concentrations were 2-fold greater in the endometriosis group than in normal subjects, but the mean values did not differ significantly. Following TRH administration, a significant increase in peak PRL concentrations was observed in patients with endometriosis (211.5 +/- 34.9 ng/ml) when compared with corresponding values in control subjects (117.1 +/- 14.9 ng/ml, P less than 0.05). This hypersecretory state was selective for PRL because no significant differences between the baseline and TRH-stimulated thyroid-stimulating hormone (TSH) concentrations or total serum thyroxine concentrations were observed. In summary, some infertile women with endometriosis exhibit a greater capacity for PRL secretion than normal women. These results suggest that relative hyperprolactinemia may be responsible for the infertility associated with endometriosis, and that PRL suppression may be indicated in these patients.
为了阐明高催乳素血症作为子宫内膜异位症患者不孕可能原因的作用，对14名患有子宫内膜异位症的不孕女性和13名正常的可育女性进行了基础血清催乳素（PRL）浓度以及PRL对促甲状腺激素释放激素（TRH）刺激反应的测定。子宫内膜异位症组的基础PRL浓度比正常受试者高2倍，但平均值无显著差异。给予TRH后，与对照组受试者的相应值（117.1±14.9 ng/ml，P<0.05）相比，子宫内膜异位症患者的PRL峰值浓度显著升高（211.5±34.9 ng/ml）。这种高分泌状态对PRL具有选择性，因为基础和TRH刺激后的促甲状腺激素（TSH）浓度或总血清甲状腺素浓度之间未观察到显著差异。总之，一些患有子宫内膜异位症的不孕女性比正常女性表现出更强的PRL分泌能力。这些结果表明，相对高催乳素血症可能是子宫内膜异位症相关不孕的原因，并且这些患者可能需要进行PRL抑制治疗。
