Shimpo K, Nagatsu T, Yamada K, Sato T, Niimi H, Shamoto M, Takeuchi T, Umezawa H, Fujita K
Institute for Comprehensive Medical Science, School of Medicine, Fujita Health University, Aichi, Japan.
Am J Clin Nutr. 1991 Dec;54(6 Suppl):1298S-1301S. doi: 10.1093/ajcn/54.6.1298s.
Adriamycin (ADR) is effective against a wide range of human neoplasms. However, its clinical use is compromised by serious cardiac toxicity, possibly through induction of peroxidation in cardiac lipids. Ascorbic acid, a potent antioxidant, was examined for effect in reducing ADR toxicity in mice and guinea pigs. Ascorbic acid had no effect on the antitumor activity of ADR in mice inoculated with leukemia L1210 or Ehrlich ascites carcinoma, but it significantly prolonged the life of animals treated with ADR. ADR elevated lipid peroxide levels in mouse heart, and ascorbic acid prevented the elevation. The significant prevention of ADR-induced cardiomyopathy in guinea pigs by ascorbic acid was proved by electron microscopy. Ascorbic acid and the derivatives may delay general toxicity of ADR and also prevent the cardiac toxicity. The results also suggest the clinical efficacy of the combined treatment of ADR and ascorbic acid or the derivatives.
阿霉素（ADR）对多种人类肿瘤有效。然而，其临床应用因严重的心脏毒性而受到限制，这种毒性可能是通过诱导心脏脂质过氧化作用产生的。抗坏血酸是一种有效的抗氧化剂，研究了其对减轻小鼠和豚鼠阿霉素毒性的作用。抗坏血酸对接种白血病L1210或艾氏腹水癌的小鼠体内阿霉素的抗肿瘤活性没有影响，但它显著延长了接受阿霉素治疗的动物的寿命。阿霉素会提高小鼠心脏中的脂质过氧化物水平，而抗坏血酸可防止这种升高。电子显微镜证实了抗坏血酸能显著预防豚鼠由阿霉素诱导的心肌病。抗坏血酸及其衍生物可能会延缓阿霉素的全身毒性，还能预防心脏毒性。结果还表明了阿霉素与抗坏血酸或其衍生物联合治疗的临床疗效。
