African Vegetables ( Leaf and Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats.

Trastuzumab () is a humanized monoclonal antibody that has been approved for the clinical management of HER2-positive metastatic breast and gastric cancers but its use is limited by its cumulative dose and off-target cardiotoxicity. Unfortunately, till date, there is no approved antidote to this off-target toxicity. Therefore, an acute study was designed at investigating the protective potential and mechanism(s) of and in -induced cardiotoxicity utilizing cardiac enzyme and oxidative stress markers and histopathological endpoints. 400 mg/kg/day and dissolved in 5% DMSO in sterile water were investigated in Wistar rats injected with 2.25 mg/kg/day/ route of for 7 days, using serum and LDH, complete lipid profile, cardiac tissue oxidative stress markers assays, and histopathological examination of -intoxicated heart tissue. Results showed that 400 mg/kg/day and profoundly attenuated increases in the serum and LDH levels but caused no significant alterations in the serum lipids and weight gain pattern in the treated rats. and profoundly attenuated alterations in the cardiac tissue oxidative stress markers' activities while improving -associated cardiac histological lesions. These results suggest that and could be mediating its cardioprotection via antioxidant, free radical scavenging, and antithrombotic mechanisms, thus, highlighting the therapeutic potentials of and in the management of -mediated cardiotoxicity.