Department of Psychiatry and Psychotherapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Department of Psychoanalysis and Psychotherapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Sci Rep. 2018 Jan 12;8(1):692. doi: 10.1038/s41598-017-19040-z.
The inconsistent findings on the association between COMT (catecholamine-O-methyl-transferase) and suicidal behaviour gave reason to choose a clear phenotype description of suicidal behaviour and take childhood maltreatment as environmental factor into account. The aim of this candidate-gene-association study was to eliminate heterogeneity within the sample by only recruiting affective disorder patients and find associations between COMT polymorphisms and defined suicidal phenotypes. In a sample of 258 affective disorder patients a detailed clinical assessment (e.g. CTQ, SCAN, HAMD, SBQ-R, VI-SURIAS, LPC) was performed. DNA of peripheral blood samples was genotyped using TaqMan® SNP Genotyping Assays. We observed that the haplotype GAT of rs737865, rs6269, rs4633 is significantly associated with suicide attempt (p = 0.003 [p = 0.021]), and that there is a tendency towards self-harming behaviour (p = 0.02 [p = 0.08]) and also NSSI (p = 0.03 [p = 0.08]), though the p values did not resist multiple testing correction. The same effect we observed with the 4-marker slide window haplotype, GATA of rs737865, rs6269, rs4633, rs4680 (p = 0.009 [p = 0.045]). The findings support an association between the COMT gene and suicidal behaviour phenotypes with and without childhood maltreatment as environmental factor.
COMT（儿茶酚-O-甲基转移酶）与自杀行为之间的关联结果不一致，这使得我们有理由选择一个明确的自杀行为表型描述，并将儿童期虐待等环境因素考虑在内。本候选基因关联研究的目的是通过仅招募情感障碍患者并发现 COMT 多态性与定义明确的自杀表型之间的关联，来消除样本中的异质性。在 258 名情感障碍患者的样本中进行了详细的临床评估（例如 CTQ、SCAN、HAMD、SBQ-R、VI-SURIAS、LPC）。使用 TaqMan® SNP 基因分型测定法对外周血样本的 DNA 进行基因分型。我们观察到 rs737865、rs6269、rs4633 的 GAT 单倍型与自杀企图显著相关（p=0.003[p=0.021]），并且存在自我伤害行为的趋势（p=0.02[p=0.08]）和 NSSI（p=0.03[p=0.08]），尽管这些 p 值没有抵抗多重测试校正。我们在 4 标记滑动窗口单倍型 GATA 中观察到了相同的效果，即 rs737865、rs6269、rs4633、rs4680 的单倍型（p=0.009[p=0.045]）。这些发现支持 COMT 基因与自杀行为表型之间存在关联，无论是否存在儿童期虐待等环境因素。
