Sauberlich H E, Wood S M, Tamura T, Freeberg L E
Department of Nutrition Sciences, University of Alabama, Birmingham 35294.
Am J Clin Nutr. 1991 Dec;54(6 Suppl):1319S-1322S. doi: 10.1093/ajcn/54.6.1319s.
D-Erythorbic acid is an epimer of L-ascorbic acid, but lacks antiscorbutic activity. It is commonly used as a food additive, particularly in processed meat items. Except for high-performance liquid chromatography (HPLC) methodology, the commonly used analytical procedures to measure vitamin C do not distinguish between the two isomers. A study with seven adult women demonstrated that the concentration of erythorbic acid present in food items commonly consumed was sufficient to produce interference in plasma vitamin C analyses. With the meals used, 7-23% of the apparent vitamin C in plasma obtained 2 h after the ingestion of the meals was actually erythorbic acid when analyzed by HPLC. To avoid falsely high plasma-serum vitamin C values as a result of erythorbic acid ingestion, the analyses should be conducted on overnight fasting blood specimens or with the use of an HPLC-amperometric method.
D -异抗坏血酸是L -抗坏血酸的差向异构体，但缺乏抗坏血病活性。它通常用作食品添加剂，尤其是在加工肉类产品中。除高效液相色谱（HPLC）方法外，常用的测定维生素C的分析程序无法区分这两种异构体。一项针对七名成年女性的研究表明，日常食用的食品中存在的异抗坏血酸浓度足以对血浆维生素C分析产生干扰。在所使用的餐食中，摄入餐食2小时后获得的血浆中，通过HPLC分析时，表观维生素C的7 - 23%实际上是异抗坏血酸。为避免因摄入异抗坏血酸导致血浆 - 血清维生素C值出现假性升高，应使用过夜空腹血标本进行分析，或采用HPLC - 安培法。
