Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA.
Eur J Nutr. 2010 Feb;49(1):1-9. doi: 10.1007/s00394-009-0042-x. Epub 2009 Jul 22.
There is evidence that disaccharide sucrose produce a greater increase in serum fructose and triglycerides (TGs) than the effect produced by their equivalent monosaccharides, suggesting that long-term exposure to sucrose or fructose + glucose could potentially result in different effects.
We studied the chronic effects of a combination of free fructose and glucose relative to sucrose on rat liver.
Rats were fed either a combination of 30% fructose and 30% glucose (FG) or 60% sucrose (S). Control rats were fed normal rat chow (C). All rats were pair fed and were followed for 4 months. After killing, blood chemistries and liver tissue were examined.
Both FG-fed- and S-fed rats developed early features of metabolic syndrome when compared with C. In addition, both diets induced hepatic alterations, including variable increases in hepatic TG accumulation and fatty liver, an increase in uric acid content in the liver, as well as an increase in hepatic levels of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) measured in liver homogenates.
Diets containing 30% of fructose either as free fructose and glucose, or as sucrose, induce metabolic syndrome, intrahepatic accumulation of uric acid and TGs, increased MCP-1 and TNF-alpha as well as fatty liver in rats. It will be relevant to determine clinically whether pharmacological reduction in uric acid levels might have a therapeutic advantage in the treatment of non-alcoholic fatty liver disease.
有证据表明，二糖蔗糖比其等效的单糖产生更大的血清果糖和甘油三酯（TGs）升高，这表明长期暴露于蔗糖或果糖+葡萄糖可能会产生不同的影响。
我们研究了游离果糖和葡萄糖的组合相对于蔗糖对大鼠肝脏的慢性影响。
大鼠分别喂食 30%果糖和 30%葡萄糖（FG）或 60%蔗糖（S）的组合。对照大鼠喂食正常大鼠饲料（C）。所有大鼠均进行配对喂养，并进行了 4 个月的随访。处死大鼠后，检测血液化学和肝组织。
与 C 相比，FG 喂养组和 S 喂养组大鼠均出现代谢综合征的早期特征。此外，两种饮食均诱导肝改变，包括肝 TG 蓄积和脂肪肝的不同程度增加、肝尿酸含量增加，以及肝匀浆中单核细胞趋化蛋白-1（MCP-1）和肿瘤坏死因子-α（TNF-α）水平升高。
含有 30%果糖的饮食，无论是游离果糖和葡萄糖，还是蔗糖，都会在大鼠中诱导代谢综合征、肝内尿酸和 TG 蓄积、MCP-1 和 TNF-α增加以及脂肪肝。临床上确定降低尿酸水平是否对治疗非酒精性脂肪性肝病具有治疗优势将是相关的。
