Department of Chemistry, Cleveland State University, Cleveland, Ohio 44115, USA.
Med Res Rev. 2010 Mar;30(2):270-89. doi: 10.1002/med.20171.
Targeted delivery of a drug or gene to its site of action has clear therapeutic advantages by maximizing its therapeutic efficiency and minimizing its systemic toxicity. Generally, targeted drug or gene delivery is performed by loading a macromolecular carrier with an appropriate drug or gene, and by targeting the drug/gene carrier to specific cell or tissue with the help of specific targeting ligand. The emergence of glycobiology, glycotechnology, and glycomics and their continual adaptation by pharmaceutical scientists have opened exciting avenue of medicinal applications of carbohydrates. Among them, the biocompatibility and specific receptor recognition ability confer the ability of carbohydrates as potential targeting ligands for targeted drug and gene delivery applications. This review summarizes recent progress of carbohydrate-decorated targeted drug/gene delivery applications.
靶向药物或基因递送到其作用部位具有明显的治疗优势，可最大限度地提高其治疗效率并最小化其全身毒性。通常，通过将适当的药物或基因装载到大分子载体上，并借助特定的靶向配体将药物/基因载体靶向特定的细胞或组织来实现靶向药物或基因递送。糖生物学、糖技术和糖组学的出现及其被药物科学家的不断采用，为碳水化合物在医学中的应用开辟了令人兴奋的途径。其中，碳水化合物的生物相容性和特定受体识别能力使它们具有作为靶向药物和基因递送应用的潜在靶向配体的能力。本文综述了近年来碳水化合物修饰的靶向药物/基因递送应用的最新进展。
