Öztürk Gündüz Ezel, Tasasız Berkan, Gedik M Emre, Günaydın Gürcan, Okutan Elif
Department of Chemistry, Faculty of Science, Gebze Technical University, Gebze, Kocaeli 41400, Turkey.
Department of Basic Oncology, Cancer Institute, Hacettepe University, Çankaya, Ankara 06800, Turkey.
ACS Omega. 2023 Feb 22;8(9):8320-8331. doi: 10.1021/acsomega.2c06900. eCollection 2023 Mar 7.
Three multifunctional targeted NI-BODIPYs (-) and -(-) nanocarriers were fabricated. NI-BODIPYs are designed to facilitate non-covalent interaction with graphene oxide (GO) and target toward cancer cells for specific recognition with glucose moieties while efficiently producing singlet oxygen. We probed detailed characterization, fundamental photophysical/photochemical properties, and interactions with GO of such triplet photosensitizers and nanocarriers. The effect of the formation of nanohybrids with GO on singlet oxygen formation as well as on the efficacies of the molecules in terms of killing of cancer cells was evaluated with K562 human chronic myelogenous leukemia cells. Amazingly, it was observed that GO exhibited favorable interactions with the NI-BODIPY dyads and promoted the formation of singlet oxygen, while not showing any dark toxicity.
制备了三种多功能靶向性镍-硼二吡咯（-）和-（-）纳米载体。镍-硼二吡咯旨在促进与氧化石墨烯（GO）的非共价相互作用，并靶向癌细胞以与葡萄糖部分进行特异性识别，同时高效产生活性单线态氧。我们探究了此类三重态光敏剂和纳米载体的详细表征、基本光物理/光化学性质以及与GO的相互作用。用K562人慢性髓性白血病细胞评估了与GO形成纳米杂化物对单线态氧形成的影响以及这些分子在杀死癌细胞方面的功效。令人惊讶的是，观察到GO与镍-硼二吡咯二元体表现出良好的相互作用并促进了单线态氧的形成，同时未显示出任何暗毒性。
