Department of Maxillofacial Surgery, Oxford Radcliffe Hospitals NHS Trust, Oxford, United Kingdom.
Head Neck. 2010 Sep;32(9):1269-72. doi: 10.1002/hed.21183.
Malakoplakia is a very rare chronic inflammatory disorder, first described in 1902. In 75% of cases, the condition affects the genitourinary tract. Five cases of malakoplakia affecting the neck were previously reported in the literature.
An 83-year-old woman presented with an enlarging mass in the posterior triangle of the neck that was histologically confirmed as malakoplakia. Presenting features are often nonspecific, and the diagnosis is dependent on histological findings. The characteristic microscopic findings are of Michaelis-Gutmann (M-G) bodies that stain positive with periodic acid-Schiff reagent, von Kossa's reaction for calcium, and Perl's ferrocyanide reaction to ferric iron.
Although rare, a diagnosis of malakoplakia should be considered in patients with an enlarging mass. This may mimic the presentation of malignancy, particularly in patients in whom erosion through skin occurs, and histological confirmation is advocated.
黏膜包涵体病是一种非常罕见的慢性炎症性疾病，于 1902 年首次描述。在 75%的病例中，该疾病影响泌尿生殖系统。先前在文献中已有 5 例发生于颈部的黏膜包涵体病的病例报道。
一位 83 岁的女性患者出现颈部后三角区增大的肿块，组织学证实为黏膜包涵体病。其临床表现通常不具特异性，且诊断依赖于组织学发现。特征性的显微镜下发现为 Michaelis-Gutmann (M-G) 体，对过碘酸希夫试剂、钙的 von Kossa 反应以及 Perl 的亚铁氰化铁反应呈阳性。
尽管罕见，但对于出现肿块增大的患者，应考虑黏膜包涵体病的诊断。这可能类似于恶性肿瘤的表现，尤其是在发生皮肤侵蚀的患者中，因此提倡进行组织学确认。
