Schlueter Nadine, Hardt Martin, Lussi Adrian, Engelmann Frank, Klimek Joachim, Ganss Carolina
Department of Conservative and Preventive Dentistry, Dental Clinic, Justus Liebig University Giessen, Giessen, Germany.
Eur J Oral Sci. 2009 Aug;117(4):427-34. doi: 10.1111/j.1600-0722.2009.00647.x.
Tin-containing fluoride solutions can reduce erosive tissue loss, but the effects of the reaction between tin and enamel are still not clear. During a 10-d period, enamel specimens were cyclically demineralized (0.05 M citric acid, pH 2.3, 6 x 5 min d(-1)) and remineralized (between the demineralization cycles and overnight). In the negative-control group, no further treatment was performed. Three groups were treated (2 x 2 min d(-1)) with tin-containing fluoride solutions (400, 1,400 or 2,100 ppm Sn2+, all 1,500 ppm F-, pH 4.5). Three additional groups were treated with test solutions twice daily, but without demineralization. Tissue loss was determined profilometrically. Energy-dispersive X-ray spectroscopy was used to measure the tin content on and within three layers (10 mum each) beneath the surface. In addition, scanning electron microscopy was conducted. All test preparations significantly reduced tissue loss. Deposition of tin on surfaces was higher without erosion than with erosion, but no incorporation of tin into enamel was found without demineralization. Under erosive conditions, both highly concentrated solutions led to the incorporation of tin up to a depth of 20 mum; the less-concentrated solution led to small amounts of tin in the outer 10 mum. The efficacy of tin-containing solutions seems to depend mainly on the incorporation of tin into enamel.
含锡氟溶液可减少侵蚀性组织损失，但锡与牙釉质之间反应的效果仍不明确。在10天的时间段内，牙釉质标本进行周期性脱矿（0.05M柠檬酸，pH2.3，每天6次，每次5分钟）和再矿化（在脱矿循环之间以及过夜）。在阴性对照组中，未进行进一步处理。三组用含锡氟溶液（400、1400或2100ppm Sn2+，均为1500ppm F-，pH4.5）处理（每天2次，每次2分钟）。另外三组每天用测试溶液处理两次，但不进行脱矿。通过轮廓测定法确定组织损失。使用能量色散X射线光谱法测量表面以下三层（每层10μm）及其内部的锡含量。此外，进行了扫描电子显微镜检查。所有测试制剂均显著减少了组织损失。在无侵蚀情况下，锡在表面的沉积高于有侵蚀时，但在无脱矿情况下未发现锡掺入牙釉质。在侵蚀条件下，两种高浓度溶液均导致锡掺入深度达20μm；浓度较低的溶液导致外层10μm中有少量锡。含锡溶液的功效似乎主要取决于锡掺入牙釉质的情况。
