Brox Julie Marie Haabeth, Tulek Amela, Sehic Amer, Mulic Aida, Utheim Tor Paaske, Khan Qalbi
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Postboks 1052 Blindern, Oslo, 0316, Norway.
Nordic Institute of Dental Materials (NIOM AS), Sognsveien 70A, Oslo, 0855, Norway.
BMC Oral Health. 2025 Mar 18;25(1):401. doi: 10.1186/s12903-025-05767-z.
Dental erosion development is affected by various factors such as types and amounts of acids, drinking habits and lifestyle choices. To prevent the onset and progression, identification of early erosive lesions as well as increased knowledge of the preventive treatment possibilities is of the importance. The aim of this study is to compare the protective effects of various fluoride compounds against dental erosion utilizing an established mouse model.
Three groups of ten young CD-1 mice were provided cola drink ad libitum during six weeks. Fluoride solutions containing metal components, TiF₄ (0.5 mol/l, pH 1.2, 9500 ppm F) and SnF₂ (0.5 mol/l, pH 2.6, 9500 ppm F), and a non-metal fluoride, NaF (0.5 mol/l, pH 8, 9500 ppm F) were applied to the molars under sedation twice a week. Additionally, one positive (acidic drink) and one negative (distilled water) control group were included. Mandibular molars were thereafter dissected and analyzed using scanning electron microscopy (SEM). The first molars were transversely ground, observed by SEM, and tooth height and dental hard tissue loss were measured. Further, pulp structure was described.
The application of metal fluorides, TiF₄ and SnF₂, resulted in the formation of a protective coating layer on the molars. The overall protective effects of fluoride compounds on the development of dental erosion were evident in increasing succession from NaF, TiF₄ to SnF₂. Molars applied NaF showed a 6% reduction in tooth tissue loss compared to the untreated positive control molars. TiF₄ and SnF₂ treated molars continued to display decreased tooth tissue loss by 37% and 67%, respectively.
The metal fluorides offer superior protection against dental erosion compared to the traditional fluoride compound. The results particularly emphasize the protective effect of SnF₂, which was most effective in preserving enamel structure and minimizing dentin exposure. This suggests that SnF₂ could be an effective option for preventing dental erosions.
牙齿酸蚀症的发展受多种因素影响，如酸的类型和数量、饮食习惯及生活方式选择。为预防其发生和进展，识别早期酸蚀性病变以及增加对预防性治疗可能性的了解至关重要。本研究的目的是利用已建立的小鼠模型比较各种氟化物对牙齿酸蚀的保护作用。
三组，每组十只年轻的CD-1小鼠，在六周内随意饮用可乐饮料。含金属成分的氟化物溶液，四氟化钛（0.5mol/l，pH值1.2，氟含量9500ppm）和氟化亚锡（0.5mol/l，pH值2.6，氟含量9500ppm），以及一种非金属氟化物，氟化钠（0.5mol/l，pH值8，氟含量9500ppm），在镇静状态下每周两次应用于磨牙。此外，设置一个阳性（酸性饮料）对照组和一个阴性（蒸馏水）对照组。之后解剖下颌磨牙，使用扫描电子显微镜（SEM）进行分析。将第一磨牙横向磨平，通过SEM观察，并测量牙高和牙齿硬组织损失。此外，描述牙髓结构。
应用金属氟化物四氟化钛和氟化亚锡后，磨牙上形成了一层保护涂层。氟化物对牙齿酸蚀发展的总体保护作用从氟化钠、四氟化钛到氟化亚锡依次增强。与未处理的阳性对照磨牙相比，应用氟化钠的磨牙牙齿组织损失减少了6%。经四氟化钛和氟化亚锡处理的磨牙牙齿组织损失分别继续减少了37%和67%。
与传统氟化物相比，金属氟化物对牙齿酸蚀具有更好的保护作用。结果特别强调了氟化亚锡的保护作用，它在保存釉质结构和减少牙本质暴露方面最有效。这表明氟化亚锡可能是预防牙齿酸蚀的有效选择。
