Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Mycoses. 2010 Nov;53(6):509-14. doi: 10.1111/j.1439-0507.2009.01750.x.
This study describes the isolation of Cryptococcus neoformans and Cryptococcus gattii from patients with chronic meningitis who were admitted to 16 Malaysian hospitals, from 2003 to 2004. Of the 96 cryptococcal cases reported over the 2-year period, 74 (77.1%) patients were male and 45 (46.9%) patients were between 30 and 39 years old. Cryptococcosis was uncommon in children. A total of 57 (59.4%) and 23 (24.0%) patients were Malay and Chinese respectively. Human immunodeficiency virus infection was the major underlying disease reported in 36 (37.5%) patients. C. neoformans var. grubii (serotype A and molecular type VNI) was the predominant Cryptococcus species isolated from 88.5% of cryptococcal cases in this country. Cryptococcal cases due to C. neoformans var. grubii were reported from all the five regions in Malaysia, with the most number of cases reported from the central and northern regions. Cryptococcus gattii (all were serotype B and molecular types VGI/II) was isolated from all regions except the southern region. Compared with a study conducted prior to the AIDS era, our findings show substantial changes in the demographical characteristics of patients.
本研究描述了从 2003 年至 2004 年间，16 家马来西亚医院收治的慢性脑膜炎患者中分离出的新型隐球菌和格特隐球菌。在两年期间报告的 96 例隐球菌病病例中，74 例（77.1%）为男性，45 例（46.9%）为 30 至 39 岁。儿童中隐球菌病并不常见。共 57 例（59.4%）和 23 例（24.0%）患者分别为马来人和华人。在 36 例（37.5%）患者中，艾滋病毒感染是主要的潜在疾病。新型隐球菌变种格氏（血清型 A 和分子型 VNI）是从该国 88.5%的隐球菌病例中分离出的主要隐球菌种类。新型隐球菌变种格氏引起的隐球菌病例报告来自马来西亚的五个地区，其中报告病例最多的是中部和北部地区。除南部地区外，所有地区均分离出格特隐球菌（均为血清型 B 和分子型 VGI/II）。与艾滋病前时代进行的研究相比，我们的发现表明患者的人口统计学特征发生了重大变化。
