Aluri Suhaas, Janib Siti M, Mackay J Andrew
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, 90033-9121, USA.
Adv Drug Deliv Rev. 2009 Sep 30;61(11):940-52. doi: 10.1016/j.addr.2009.07.002. Epub 2009 Jul 20.
The tumor microenvironment provides multiple cues that may be exploited to improve the efficacy of established chemotherapeutics; furthermore, polypeptides are uniquely situated to capitalize on these signals. Peptides provide: 1) a rich repertoire of biologically specific interactions to draw upon; 2) environmentally responsive phase behaviors, which may be tuned to respond to signatures of disease; 3) opportunities to direct self-assembly; 4) control over routes of biodegradation; 5) the option to seamlessly combine functionalities into a single polymer via a one-step biosynthesis. As development of cancer-targeted nanocarriers expands, peptides provide a unique source of functional units that may target disease. This review explores potential microenvironmental physiology indicative of tumors and peptides that have demonstrated an ability to target and deliver to these signals.
肿瘤微环境提供了多种线索，可用于提高现有化疗药物的疗效；此外，多肽在利用这些信号方面具有独特的优势。肽具有以下特点：1）拥有丰富的生物特异性相互作用可供利用；2）具有环境响应性相行为，可进行调节以响应疾病特征；3）有机会引导自组装；4）可控制生物降解途径；5）能够通过一步生物合成将多种功能无缝整合到单一聚合物中。随着癌症靶向纳米载体的发展不断扩大，肽提供了可靶向疾病的独特功能单元来源。本综述探讨了指示肿瘤的潜在微环境生理学以及已证明能够靶向并传递至这些信号的肽。
