Department of Biomedical Engineering, PO Box 90281, Duke University, Durham, NC 27708, USA.
Nanomedicine (Lond). 2010 Jul;5(5):793-806. doi: 10.2217/nnm.10.50.
Nanoparticles and macromolecular carriers have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Stimulus-responsive peptide and polymer vehicles can further enhance the efficacy of antitumor therapeutics compared with the administration of free drug by three mechanisms: increasing the overall accumulation within solid tumors; providing a homogeneous spatial distribution in tumor tissues; and increasing the intracellular localization of anticancer therapeutics. This article highlights recent developments in 'smart' - stimulus-responsive - peptide, polymer and lipid drug carriers designed to enhance the localization and efficacy of therapeutic payloads as compared with free drug.
纳米粒子和高分子载体已被广泛用于提高化疗药物的疗效,主要是通过增强的通透性和保留效应提供的被动积累。与给予游离药物相比,刺激响应性肽和聚合物载体通过三种机制进一步增强抗肿瘤治疗药物的疗效:增加实体瘤内的整体积累;在肿瘤组织中提供均匀的空间分布;并增加抗癌治疗药物的细胞内定位。本文重点介绍了近年来设计的“智能”-刺激响应性-肽、聚合物和脂质药物载体的最新进展,与游离药物相比,这些载体旨在增强治疗有效载荷的定位和疗效。