Department of Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, People's Republic of China.
Drug Deliv. 2021 Dec;28(1):37-53. doi: 10.1080/10717544.2020.1856225.
Some cancers such as human breast cancer, prostate cancer, and lung cancer easily metastasize to bone, leading to osteolysis and bone destruction accompanied by a complicated microenvironment. Systemic administration of bisphosphonates (BP) or denosumab is the routine therapy for osteolysis but with non-negligible side effects such as mandibular osteonecrosis and hypocalcemia. Thus, it is imperative to exploit optimized drug delivery systems, and some novel nanotechnology and nanomaterials have opened new horizons for scientists. Targeted and local drug delivery systems can optimize biodistribution depending on nanoparticles (NPs) or microspheres (MS) and implantable biomaterials with the controllable property. Drug delivery kinetics can be optimized by smart and sustained/local drug delivery systems for responsive delivery and sustained delivery. These delicately fabricated drug delivery systems with special matrix, structure, morphology, and modification can minimize unexpected toxicity caused by systemic delivery and achieve desired effects through integrating multiple drugs or multiple functions. This review summarized recent studies about optimized drug delivery systems for the treatment of cancer metastatic osteolysis, aimed at giving some inspiration in designing efficient multifunctional drug delivery systems.
一些癌症，如乳腺癌、前列腺癌和肺癌，很容易转移到骨骼，导致溶骨性和骨破坏，并伴有复杂的微环境。双膦酸盐（BP）或地舒单抗的全身给药是治疗溶骨性疾病的常规疗法，但存在不可忽视的副作用，如下颌骨坏死和低钙血症。因此，迫切需要开发优化的药物递送系统，一些新的纳米技术和纳米材料为科学家们开辟了新的视野。基于纳米颗粒（NPs）或微球（MS）和可植入生物材料的靶向和局部药物递送系统可以根据其可控特性优化生物分布。通过智能和持续/局部药物递送系统优化药物递送动力学，以实现响应性和持续递送。这些精心设计的药物递送系统具有特殊的基质、结构、形态和修饰，可以最大限度地减少全身给药引起的意外毒性，并通过整合多种药物或多种功能来达到预期的效果。本综述总结了最近关于治疗癌症转移性溶骨性疾病的优化药物递送系统的研究，旨在为设计高效多功能药物递送系统提供一些启示。
