在以拉丁裔为主的人群中，转化生长因子β3基因的母婴变异与妊娠期高血压风险
Maternal and fetal variants in the TGF-beta3 gene and risk of pregnancy-induced hypertension in a predominantly Latino population.
作者信息
Wilson Melissa L, Desmond Daniel H, Goodwin T Murphy, Miller David A, Ingles Sue Ann
机构信息
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
出版信息
Am J Obstet Gynecol. 2009 Sep;201(3):295.e1-5. doi: 10.1016/j.ajog.2009.05.038. Epub 2009 Jul 22.
OBJECTIVE
We sought to determine whether polymorphisms in the transforming growth factor (TGF)-beta3 gene are associated with risk of pregnancy-induced hypertension (PIH) in case-control mother-baby dyads.
STUDY DESIGN
Patients (n = 136) and control subjects (n = 169) were recruited from our hospital. We genotyped 4 TGF-beta3 polymorphisms and examined association with PIH using logistic regression, adjusting for parity, maternal age, gestational age at delivery, fetal (or maternal) genotypes for the polymorphism in question, and the 3 other polymorphisms within the TGF-beta3 gene.
RESULTS
Only 1 of the TGF-beta3 polymorphisms (rs11466414) was associated with PIH. Mothers who carried a baby with a minor allele were at decreased risk (odds ratio(multi-locus adj), 0.32; 95% confidence interval, 0.14-0.77). Maternal TGF-beta3 variants had no effect on risk of PIH.
CONCLUSION
A fetal TGF-beta3 polymorphism (rs11466414) is associated with PIH in a predominantly Hispanic population.
目的
我们试图确定转化生长因子（TGF）-β3基因多态性是否与病例对照母婴二元组中妊娠高血压（PIH）的风险相关。
研究设计
从我院招募患者（n = 136）和对照受试者（n = 169）。我们对4种TGF-β3多态性进行基因分型，并使用逻辑回归分析其与PIH的关联，同时校正产次、母亲年龄、分娩时的孕周、所研究多态性的胎儿（或母亲）基因型以及TGF-β3基因内的其他3种多态性。
结果
仅1种TGF-β3多态性（rs11466414）与PIH相关。携带小等位基因婴儿的母亲风险降低（比值比（多位点校正），0.32；95%置信区间，0.14 - 0.77）。母亲的TGF-β3变体对PIH风险无影响。
结论
在主要为西班牙裔的人群中，胎儿TGF-β3多态性（rs11466414）与PIH相关。
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