Department of Pathology, Chi-Mei Medical Center, Tainan 710, Taiwan.
Pathol Res Pract. 2010 Jul 15;206(7):463-6. doi: 10.1016/j.prp.2009.07.001. Epub 2009 Jul 22.
Nasal and nasal-type NK/T-cell lymphomas are predominantly extranodal tumors with a specific immunophenotype and a strong association with EBV. The cutaneous lymphocyte-associated antigen (CLA) is the homing receptor for skin-homing T cells and NK cells. In the literature, the prognostic impact of CLA expression in primary cutaneous T-cell lymphomas and nasal NK-cell lymphomas is contradictory. We present 2 non-nasal NK-cell lymphomas with nodal presentation. Both tumors showed the phenotype of CD3+ (cytoplasmic), CD5-, CD7-, CD16+, CD56+, cytotoxic molecules+, EBV+ (by in situ hybridization), and CLA+. They were polyclonal for T-cell receptor gamma chain gene rearrangement, indicating an NK cell lineage. The aggressive course in these two patients suggested that in nasal and nasal-type NK-cell lymphomas, CLA expression might be an indicator of poor prognosis. More studies are needed to elucidate the prognostic impact of CLA expression in T cell and NK-cell lymphomas.
鼻腔和鼻型 NK/T 细胞淋巴瘤主要是结外肿瘤，具有特定的免疫表型，与 EBV 强烈相关。皮肤淋巴细胞相关抗原 (CLA) 是皮肤归巢 T 细胞和 NK 细胞的归巢受体。在文献中，CLA 表达在原发性皮肤 T 细胞淋巴瘤和鼻 NK 细胞淋巴瘤中的预后影响是矛盾的。我们报告了 2 例结外 NK 细胞淋巴瘤。这两种肿瘤均表现为 CD3+（细胞质）、CD5-、CD7-、CD16+、CD56+、细胞毒性分子+、EBV+（原位杂交）和 CLA+。它们的 T 细胞受体 γ 链基因重排呈多克隆性，表明 NK 细胞谱系。这两例患者的侵袭性病程表明，在鼻腔和鼻型 NK 细胞淋巴瘤中，CLA 表达可能是预后不良的指标。需要更多的研究来阐明 CLA 表达在 T 细胞和 NK 细胞淋巴瘤中的预后影响。
