Matzhold Eva M, Trummer Olivia, Grünbacher Gerda, Zulus Barbara, Boehm Bernhard O, März Winfried, Renner Wilfried
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University, Graz, Austria.
Cytokine. 2009 Sep;47(3):224-7. doi: 10.1016/j.cyto.2009.06.010. Epub 2009 Jul 22.
Two chemokine receptor CX3CR1 gene variants, V249I and T280M, have been implicated in coronary artery diseases (CAD). Currently no consistent effect has been revealed and their role in cardiovascular disease is still conflicting. In the present study the association of CX3CR1 genotypes with CAD and myocardial infarction (MI) was investigated in the Ludwigshafen Risk and Cardiovascular Health (LURIC) cohort, including 3316 individuals in whom cardiovascular disease angiographically has been defined or ruled out. Similarly to previous studies, the alleles I249 and M280 were in strong linkage disequilibrium and formed an I(249)M(280) haplotype. However, there was no relationship between CX3CR1 genotypes or corresponding haplotypes and the prevalence of CAD or MI. Adjusted for classical risk factors (age, sex, hypertension, dyslipidemia, diabetes mellitus and smoking), the odds ratio (OR) of V249I for CAD was 0.95 (95% confidence interval (CI)=0.78-1.15, p=0.61). The OR of T280M for CAD was 0.83 (95% CI=0.66-1.04, p=0.11). Furthermore, CX3CR1 variants were not associated with C-reactive protein levels, age at onset of CAD, severity of CAD and MI. In conclusion, present data of LURIC do not support the hypothesis that common variants of the CX3CR1 gene are associated with the presence of CAD or MI.
两种趋化因子受体CX3CR1基因变体V249I和T280M与冠状动脉疾病（CAD）有关。目前尚未发现一致的效应，它们在心血管疾病中的作用仍存在争议。在本研究中，在路德维希港风险与心血管健康（LURIC）队列中调查了CX3CR1基因分型与CAD和心肌梗死（MI）的关联，该队列包括3316名经血管造影确定或排除心血管疾病的个体。与先前的研究相似，等位基因I249和M280处于强连锁不平衡状态，并形成了I(249)M(280)单倍型。然而，CX3CR1基因分型或相应单倍型与CAD或MI的患病率之间没有关系。在对经典危险因素（年龄、性别、高血压、血脂异常、糖尿病和吸烟）进行校正后，V249I对CAD的优势比（OR）为0.95（95%置信区间（CI）=0.78-1.15，p=0.61）。T280M对CAD的OR为0.83（95%CI=0.66-1.04，p=0.11）。此外，CX3CR1变体与C反应蛋白水平、CAD发病年龄、CAD和MI的严重程度无关。总之，LURIC的现有数据不支持CX3CR1基因常见变体与CAD或MI存在相关的假设。
