Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, 226014 Uttar Pradesh, India.
Mol Biol Rep. 2012 Mar;39(3):2753-9. doi: 10.1007/s11033-011-1031-8. Epub 2011 Jul 10.
Chemokines regulates the trafficking of leukocytes to the site of inflammation hence may be implicated in cardiac events. Currently no consistent effects have been revealed their role in acute myocardial infarction (MI). The aim of current study was to investigate the impact of human chemokine receptor genetic variants, CCR5-Δ32 insertion/deletion, CCR5-59029-A/G, CX3CR1-V249I and CX3CR1-T280 M on acute MI. 230 acute MI and 300 controls were examined. Patients carrying CCR5-Δ32 genotype were at three times higher risk of developing MI odds ratio (OR, 3.24, CI 1.127-9.356, P = 0.04). Significant association was found with risk of acute MI in recipients who possessed homozygous 59029-A allele (OR 1.47, CI 1.03-2.09, P = 0.03). While CX3CR1-I249 and M280 were found to be protective in MI patients with OR 0.46, CI 0.32-0.66, P < 0.0001 and OR 0.36, CI 0.24-0.55, P < 0.0001, respectively. It might be possible that risk of acute MI is associated with genetic variation in chemokine receptors, i.e., CCR5 and CX3CR1.
趋化因子调节白细胞向炎症部位的迁移，因此可能与心脏事件有关。目前，尚未发现它们在急性心肌梗死 (MI) 中的作用具有一致性。本研究旨在探讨人类趋化因子受体遗传变异，即 CCR5-Δ32 插入/缺失、CCR5-59029-A/G、CX3CR1-V249I 和 CX3CR1-T280M 对急性 MI 的影响。共检测了 230 例急性 MI 患者和 300 例对照者。携带 CCR5-Δ32 基因型的患者发生 MI 的风险增加了三倍（比值比，3.24，95%置信区间，1.127-9.356，P=0.04）。在携带纯合 59029-A 等位基因的患者中，发现与急性 MI 风险显著相关（比值比，1.47，95%置信区间，1.03-2.09，P=0.03）。而 CX3CR1-I249 和 M280 被发现对 MI 患者具有保护作用，比值比分别为 0.46（95%置信区间，0.32-0.66，P<0.0001）和 0.36（95%置信区间，0.24-0.55，P<0.0001）。这表明，急性 MI 的风险可能与趋化因子受体（即 CCR5 和 CX3CR1）的遗传变异有关。
