Wannamethee S Goya, Whincup Peter H, Thomas Mary C, Sattar Naveed
Department of Primary Care and Population Health, University College Medical School, Hampstead Campus, University College London, London, UK.
Diabetes Care. 2009 Oct;32(10):1823-5. doi: 10.2337/dc09-0477. Epub 2009 Jul 23.
To examine the relationship between dietary fiber and the risk of type 2 diabetes in older men and the role of hepatic and inflammatory markers.
The study was performed prospectively and included 3,428 nondiabetic men (age 60-79 years) followed up for 7 years, during which there were 162 incident cases of type 2 diabetes.
Low total dietary fiber (lowest quartile < or =20 g/day) was associated with increased risk of diabetes after adjustment for total calorie intake and potential confounders (relative risk -1.47 [95% CI 1.03-2.11]). This increased risk was seen separately for both low cereal and low vegetable fiber intake. Dietary fiber was inversely associated with inflammatory markers (C-reactive protein, interleukin-6) and with tissue plasminogen activator and gamma-glutamyl transferase. Adjustment for these markers attenuated the increased risk (1.28 [0.88-1.86]).
Dietary fiber is associated with reduced diabetes risk, which may be partly explained by inflammatory markers and hepatic fat deposition.
研究膳食纤维与老年男性2型糖尿病风险之间的关系以及肝脏和炎症标志物的作用。
本研究为前瞻性研究，纳入3428名非糖尿病男性（年龄60 - 79岁），随访7年，期间有162例2型糖尿病新发病例。
在调整总热量摄入和潜在混杂因素后，低膳食纤维总量（最低四分位数<或=20克/天）与糖尿病风险增加相关（相对风险-1.47 [95%可信区间1.03 - 2.11]）。低谷物纤维摄入量和低蔬菜纤维摄入量分别呈现这种风险增加。膳食纤维与炎症标志物（C反应蛋白、白细胞介素-6）以及组织纤溶酶原激活物和γ-谷氨酰转移酶呈负相关。对这些标志物进行调整后，风险增加有所减弱（1.28 [0.88 - 1.86]）。
膳食纤维与降低糖尿病风险相关，这可能部分由炎症标志物和肝脏脂肪沉积来解释。
