Bo Simona, Durazzo Marilena, Guidi Sabrina, Carello Monica, Sacerdote Carlotta, Silli Barbara, Rosato Rosalba, Cassader Maurizio, Gentile Luigi, Pagano Gianfranco
Department of Internal Medicine, University of Turin, Turin, Italy, and the Diabetic Clinic, Hospital of Asti, Italy.
Am J Clin Nutr. 2006 Nov;84(5):1062-9. doi: 10.1093/ajcn/84.5.1062.
Type 2 diabetes (DM), metabolic syndrome (MetS), and inflammation are linked to reduced magnesium and fiber intakes; these associations are attenuated by adjustment for each of these nutrients.
We investigated the association among magnesium and fiber intakes, metabolic variables, and high-sensitivity C-reactive protein (hs-CRP) values.
Cross-sectional analyses were performed in a representative cohort of 1653 adults and in a subgroup with normal body mass index without dysmetabolisms (n = 205). A validated semiquantitative food-frequency questionnaire was used; magnesium intake was computed by multiplying its content in each food by the frequency of food consumption.
The prevalence of DM, MetS, and hs-CRP >/= 3 mg/L significantly decreased from the lowest to the highest tertile of magnesium and fiber intakes. Subjects within the lowest tertiles of magnesium and fiber intakes were 3-4 times as likely to have DM, MetS, and hs-CRP >/= 3 mg/L, after multiple adjustments. After the analysis was additionally controlled for fiber intake, associations with hs-CRP >/= 3 mg/L proved to be significant (odds ratio: 2.05; 95% CI: 1.30, 3.25), whereas reduced magnesium intake and DM and MetS were no longer significant. The lowest tertile of fiber intake remained associated with DM, hs-CRP >/= 3 mg/L, and MetS after adjustments for multiple confounders and magnesium intake. In the lean, healthy subject subgroup, hs-CRP values were inversely associated with magnesium and fiber intakes in a multivariate model (P < 0.001).
Reduced fiber intake was significantly associated with metabolic abnormalities; the magnesium effect might be confounded by fiber being in foods that also provided magnesium. Lower magnesium and fiber intakes were linked to hs-CRP >/= 3 mg/L in both the entire cohort and healthy persons.
2型糖尿病（DM）、代谢综合征（MetS）和炎症与镁和纤维摄入量减少有关；对这些营养素中的每一种进行调整后，这些关联会减弱。
我们研究了镁和纤维摄入量、代谢变量与高敏C反应蛋白（hs-CRP）值之间的关联。
对1653名成年人的代表性队列以及体重指数正常且无代谢紊乱的亚组（n = 205）进行横断面分析。使用经过验证的半定量食物频率问卷；通过将每种食物中的镁含量乘以食物消费频率来计算镁摄入量。
从镁和纤维摄入量的最低三分位数到最高三分位数，DM、MetS和hs-CRP≥3 mg/L的患病率显著降低。经过多次调整后，镁和纤维摄入量处于最低三分位数的受试者患DM、MetS和hs-CRP≥3 mg/L的可能性是其他人的3至4倍。在分析中进一步控制纤维摄入量后，与hs-CRP≥3 mg/L的关联被证明具有显著性（优势比：2.05；95%置信区间：1.30, 3.25），而镁摄入量减少与DM和MetS不再具有显著性。在对多个混杂因素和镁摄入量进行调整后，纤维摄入量的最低三分位数仍与DM、hs-CRP≥3 mg/L和MetS相关。在瘦的健康受试者亚组中，在多变量模型中hs-CRP值与镁和纤维摄入量呈负相关（P < 0.001）。
纤维摄入量减少与代谢异常显著相关；镁的作用可能因纤维存在于同时也提供镁的食物中而受到混淆。在整个队列和健康人群中，较低的镁和纤维摄入量都与hs-CRP≥3 mg/L有关。
