Tansel Ozlem, Ekuklu Galip, Eker Alper, Kunduracilar Hakan, Yuluğkural Zerrin, Yüksel Pelin
Department of Infectious Diseases and Clinical Microbiology, Medical Faculty of Trakya University, Edirne, Turkey.
Jpn J Infect Dis. 2009 Jul;62(4):275-8.
The aim of this study was to evaluate the seroprevalence and correlates of diphtheria and tetanus in Edirne, Turkey. Tetanus and diphtheria antitoxin levels were determined by enzyme-linked immunosorbent assay. Among 99 participants, a diphtheria antitoxin level of >or=0.1 IU/mL was found in 97 (98%), while 2 (2%) had antitoxin levels of 0.011-0.099 IU/mL. The geometric mean titres (GMTs) in men were statistically higher. Among 295 participants, a tetanus antitoxin level of >or=0.1 IU/mL was found in 291 (98.6%), while 4 (1.4%) had antitoxin levels of 0.011-0.099 IU/mL. Participants who had completed secondary school or higher education showed higher GMT values. Additionally, participants vaccinated within the previous 5 years had higher GMT values and the percentage of participants who had completed secondary school or higher education was higher among them. GMTs decrease with increasing age and increase as the poverty index increases. The average socioeconomic status index of the participants was high for both diphtheria and tetanus seroepidemiology. In this community-based study, antitoxin levels of diphtheria and tetanus were high. However, revaccination of adults with tetanus-diphtheria toxoids at every opportunity (military service, pregnancy, post-injury prophylaxis, etc.) together with a single booster every 10 years should be considered as an immunization policy.
本研究旨在评估土耳其埃迪尔内市白喉和破伤风的血清流行率及其相关因素。采用酶联免疫吸附测定法测定破伤风和白喉抗毒素水平。99名参与者中，97人（98%）的白喉抗毒素水平≥0.1 IU/mL，2人（2%）的抗毒素水平为0.011 - 0.099 IU/mL。男性的几何平均滴度（GMT）在统计学上更高。295名参与者中，291人（98.6%）的破伤风抗毒素水平≥0.1 IU/mL，4人（1.4%）的抗毒素水平为0.011 - 0.099 IU/mL。完成中学或更高教育的参与者显示出更高的GMT值。此外，在过去5年内接种过疫苗的参与者的GMT值更高，且其中完成中学或更高教育的参与者比例更高。GMT随着年龄的增长而降低，随着贫困指数的增加而升高。对于白喉和破伤风血清流行病学而言，参与者的平均社会经济地位指数较高。在这项基于社区的研究中，白喉和破伤风的抗毒素水平较高。然而，应考虑将在每次机会（兵役、怀孕、受伤后预防等）对成年人重新接种破伤风 - 白喉类毒素以及每10年进行一次单剂加强接种作为免疫策略。
