Fatholahzadeh Bahram, Emaneini Mohammad, Aligholi Marzieh, Gilbert Gwendolyn, Taherikalani Morovat, Jonaidi Nematollah, Eslampour Mohammad A, Feizabadi Mohammad M
Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Jpn J Infect Dis. 2009 Jul;62(4):309-11.
A total of 52 methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates were collected from patients attending the teaching hospital of Tehran University of Medical Sciences. Disks containing antibiotics were used to determine the susceptibility of MRSA isolates. Analysis of SmaI macrorestriction profiles of the 52 MRSA isolates were grouped into three PFGE types. The majority of isolates (n=49) were clustered into only one major PFGE type, designated as pulsotype A; these belonged to SCCmec type III or IIIA and showed resistance to ampicillin, ciprofloxacin, cotrimoxazole, erythromycin, gentamicin, and tetracycline. The remaining isolates fell into pulsotypes B and C, both belonging to SCCmec-type IV. All MRSA isolates were susceptible to vancomycin, teicoplanin, quinupristin-dalfopristin, linezolid, and tigecycline. The present study shows that a MRSA clone similar to the Brazilian clone (ST 239) of MRSA, which is a multiresistant MRSA clone with a high level of methicillin resistance, is very common in this teaching hospital in Tehran.
从德黑兰医科大学教学医院的患者中总共收集了52株耐甲氧西林金黄色葡萄球菌（MRSA）临床分离株。使用含抗生素的纸片来测定MRSA分离株的药敏性。对52株MRSA分离株的SmaI酶切脉冲场凝胶电泳（PFGE）图谱分析将其分为三种PFGE型。大多数分离株（n = 49）聚为单一的主要PFGE型，命名为脉冲型A；这些分离株属于SCCmecⅢ型或ⅢA型，对氨苄西林、环丙沙星、复方新诺明、红霉素、庆大霉素和四环素耐药。其余分离株分为脉冲型B和C，均属于SCCmecⅣ型。所有MRSA分离株对万古霉素、替考拉宁、奎奴普丁-达福普汀、利奈唑胺和替加环素敏感。本研究表明，与巴西MRSA克隆株（ST 239）相似的MRSA克隆，即一种具有高水平甲氧西林耐药性的多重耐药MRSA克隆，在德黑兰的这家教学医院非常常见。
