Mond Jonathan M, Baune Bernhard T
School of Biomedical & Health Science, University of Western Sydney, Campbelltown, New South Wales, Australia.
Obesity (Silver Spring). 2009 Aug;17(8):1627-34. doi: 10.1038/oby.2009.27. Epub 2009 Feb 19.
Associations among gender, overweight and obesity, medical comorbidity, and health-related quality of life (HRQoL) were examined in a general population sample of 4,181 women and men aged 18-65 years. Anthropometric measurements and medical comorbidity were assessed as part of a computer-assisted physician interview. HRQoL was assessed with the Physical and Mental Component Summary scales of the Medical Outcomes Study Short Form (SF-36 PCS, MCS). General linear models were used to examine the associations among gender, weight status, medical comorbidity, and HRQoL. Controlling for age, social status, the occurrence of specific medical conditions, and the total number of medical conditions, mild obesity was associated with impairment in physical health functioning, as measured by the PCS, among women, whereas impairment in men's physical health was apparent only for moderate obesity. There was no association between weight status and psycho-social functioning, as measured by the MCS, in women, whereas overweight was associated with better perceived psycho-social functioning in men. The findings are consistent with the hypothesis that women suffer a disproportionately large share of the disease burden of overweight and obesity that is not due solely to differences in medical comorbidity. The possibility that aspects of emotional well-being may mediate the association between obesity and physical health functioning warrants further attention in this regard. The findings also indicate the need to stratify data by gender and to include more sensitive measures of psycho-social functioning in future studies.
在一个由4181名年龄在18至65岁之间的男性和女性组成的普通人群样本中，研究了性别、超重与肥胖、合并症以及健康相关生活质量（HRQoL）之间的关联。人体测量和合并症作为计算机辅助医生访谈的一部分进行评估。HRQoL使用医学结局研究简表（SF-36 PCS、MCS）的身体和心理成分汇总量表进行评估。使用一般线性模型来研究性别、体重状况、合并症和HRQoL之间的关联。在控制年龄、社会地位、特定疾病的发生情况以及疾病总数后，轻度肥胖与女性中通过PCS测量的身体健康功能受损有关，而男性的身体健康受损仅在中度肥胖时明显。在女性中，体重状况与通过MCS测量的心理社会功能之间没有关联，而超重与男性中更好的心理社会功能感知有关。这些发现与以下假设一致：女性在超重和肥胖的疾病负担中所占比例过大，这并非仅仅由于合并症的差异。情绪健康方面可能介导肥胖与身体健康功能之间关联的可能性值得在这方面进一步关注。研究结果还表明，在未来的研究中有必要按性别对数据进行分层，并纳入更敏感的心理社会功能测量方法。
