胰腺癌——存活率低。
Pancreatic cancer--low survival rates.
机构信息
Abteilung für Allgemein- und Viszeralchirurgie, Klinikum der Universität Ulm, Steinhövelstrasse 9, Ulm, Germany.
出版信息
Dtsch Arztebl Int. 2008 Apr;105(14):255-62. doi: 10.3238/arztebl.2008.0255. Epub 2008 Apr 4.
INTRODUCTION
Cancers of the pancreas are identified in 11 800 to 13 500 patients each year in Germany. Epidemiological studies prove smoking and chronic alcohol consumption as causes of about 30% of pancreatic cancers.
METHODS
Selective literature review.
RESULTS
Only patients within TNM stage I and II have after oncologic tumor extirpation a chance for long term survival. Controlled prospective clinical trials demonstrated adjuvant chemotherapy yielding an additional significant survival benefit. The 3- and 5-year-survival after R0-resection and adjuvant chemotherapy are about 30% and below 15% respectively. Using the criteria of observed 5-year-survival less than 2% of all pancreatic cancer patients are alive. After R0-resection the median survival time is between 17 and 28 months, after R1/2-resection between 8 and 22 months.
DISCUSSION
Pancreatic cancer is even today for more than 95% of the patients incurable. Strategies to prevent pancreatic cancer are intended to stop smoking and chronic alcohol consumption and early surgical extirpation of cystic neoplastic lesions. For patients with established pancreatic cancer risk a follow-up protocol is discussed.
简介
在德国，每年约有 11800 至 13500 名患者被确诊患有胰腺癌。流行病学研究证明，吸烟和慢性酒精摄入是约 30%胰腺癌的病因。
方法
选择性文献回顾。
结果
只有在 TNM 分期 I 期和 II 期的患者，在进行肿瘤根治性切除术后才有长期生存的机会。对照性前瞻性临床试验表明，辅助化疗可带来显著的生存获益。R0 切除术后和辅助化疗后的 3 年和 5 年生存率分别约为 30%和低于 15%。根据观察到的 5 年生存率标准，不到 2%的胰腺癌患者存活。R0 切除术后的中位生存时间为 17 至 28 个月，R1/2 切除术后为 8 至 22 个月。
讨论
即使在今天，胰腺癌对于超过 95%的患者来说仍是不可治愈的。预防胰腺癌的策略旨在停止吸烟和慢性酒精摄入，并早期手术切除囊性肿瘤病变。对于已经患有胰腺癌风险的患者，我们讨论了一种随访方案。
Zotero 插件