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自膨式金属支架缓解复发性胃癌所致恶性吻合口狭窄的临床疗效

Clinical outcomes of self-expandable metal stents in palliation of malignant anastomotic strictures caused by recurrent gastric cancer.

作者信息

Cho Yu Kyung, Kim Sang Woo, Nam Kwan Woo, Chang Jae Hyuck, Park Jae Myung, Jeong Jeong-Jo, Lee In Seok, Choi Myung-Gyu, Chung In-Sik

机构信息

Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, 505 Banpodong, Seochogu, Seoul 137-040, South Korea.

出版信息

World J Gastroenterol. 2009 Jul 28;15(28):3523-7. doi: 10.3748/wjg.15.3523.

Abstract

AIM

To examine the technical feasibility and clinical outcomes of the endoscopic insertion of a self-expandable metal stent (SEMS) for the palliation of a malignant anastomotic stricture caused by recurrent gastric cancer.

METHODS

The medical records of patients, who had obstructive symptoms caused by a malignant anastomotic stricture after gastric surgery and underwent endoscopic insertion of a SEMS from January 2001 to December 2007 at Kangnam St Mary's Hospital, were reviewed retrospectively.

RESULTS

Twenty patients (15 male, mean age 63 years) were included. The operations were a total gastrectomy with esophagojejunostomy (n = 12), subtotal gastrectomy with Billroth-I reconstruction (n = 2) and subtotal gastrectomy with Billroth-II reconstruction (n = 8). The technical and clinical success rates were 100% and 70%, respectively. A small bowel or colon stricture was the reason for a lack of improvement in symptoms in 4 patients. Two of these patients showed improvement in symptoms after another stent was placed. Stent reobstruction caused by tumor ingrowth or overgrowth occurred in 3 patients (15%) within 1 mo after stenting. Stent migration occurred with a covered stent in 3 patients who underwent a subtotal gastrectomy with Billroth-II reconstruction. Two cases of partial stent migration were easily treated with a second stent or stent repositioning. The median stent patency was 56 d (range, 5-439 d). The median survival was 83 d (range, 12-439 d).

CONCLUSION

Endoscopic insertion of a SEMS provides safe and effective palliation of a recurrent anastomotic stricture caused by gastric cancer. A meticulous evaluation of the presence of other strictures before inserting the stent is essential for symptom improvement.

摘要

目的

探讨内镜下置入自膨式金属支架(SEMS)缓解复发性胃癌所致恶性吻合口狭窄的技术可行性及临床疗效。

方法

回顾性分析2001年1月至2007年12月在江南圣母医院因胃手术后恶性吻合口狭窄出现梗阻症状并接受内镜下SEMS置入术的患者病历。

结果

纳入20例患者(男性15例,平均年龄63岁)。手术方式包括全胃切除食管空肠吻合术(n = 12)、毕Ⅰ式胃大部切除术(n = 2)和毕Ⅱ式胃大部切除术(n = 8)。技术成功率和临床成功率分别为100%和70%。4例患者症状未改善的原因是小肠或结肠狭窄。其中2例患者在置入另一枚支架后症状改善。3例患者(15%)在支架置入后1个月内出现肿瘤长入或过度生长导致的支架再梗阻。3例行毕Ⅱ式胃大部切除术的患者使用覆膜支架后发生支架移位。2例部分支架移位病例通过再次置入支架或重新定位支架轻松得到处理。支架通畅的中位时间为56天(范围5 - 439天)。中位生存期为83天(范围12 - 439天)。

结论

内镜下置入SEMS可安全有效地缓解复发性胃癌吻合口狭窄。在置入支架前仔细评估是否存在其他狭窄对改善症状至关重要。

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