Chen Mai-Lin, Zeng Qing-Yu, Huo Jian-Wei, Yin Xiao-Ming, Li Bao-Ping, Liu Jian-Xin
Department of Radiology, China Meitan General Hospital, 29 Xibahe Nanli, Chaoyang District, Beijing 100028, China.
World J Gastroenterol. 2009 Jul 28;15(28):3532-7. doi: 10.3748/wjg.15.3532.
To assess the hepatic microvascular parameters in patients with liver cirrhosis by perfusion computed tomography (CT).
Perfusion CT was performed in 29 patients without liver disease (control subjects) and 39 patients with liver cirrhosis, including 22 patients with compensated cirrhosis and 17 patients with decompensated cirrhosis, proved by clinical and laboratory parameters. CT cine-scans were obtained over 50 s beginning with the injection of 50 mL of contrast agent. Hepatic microvascular parameters, mean transit time (MTT) and permeability surface area product (PS) were obtained with the Perfusion 3 software (General Electric, ADW 4.2).
The overall differences of MTT and PS between control subjects, patients with compensated cirrhosis and those with decompensated cirrhosis were statistically significant (P = 0.010 and P = 0.002, respectively). MTT values were 15.613 +/- 4.1746 s, 12.592 +/- 4.7518 s, and 11.721 +/- 4.5681 s for the three groups, respectively, while PS were 18.945 +/- 7.2347 mL/min per 100 mL, 22.767 +/- 8.3936 mL/min per 100 mL, and 28.735 +/- 13.0654 mL/min per 100 mL. MTT in decompensated cirrhotic patients were significantly decreased compared to controls (P = 0.017), whereas PS values were remarkably increased (P = 0.001).
The hepatic microvascular changes in patients with liver cirrhosis can be quantitatively assessed by perfusion CT. Hepatic microvascular parameters (MTT and PS), as measured by perfusion CT, were significantly altered in decompensated cirrhosis.
通过灌注计算机断层扫描（CT）评估肝硬化患者的肝脏微血管参数。
对29例无肝脏疾病的患者（对照组）和39例肝硬化患者进行灌注CT检查，其中肝硬化患者包括22例代偿期肝硬化患者和17例失代偿期肝硬化患者，均经临床和实验室参数证实。在注入50 mL造影剂后开始进行50秒的CT电影扫描。使用Perfusion 3软件（通用电气，ADW 4.2）获得肝脏微血管参数，即平均通过时间（MTT）和通透表面积乘积（PS）。
对照组、代偿期肝硬化患者和失代偿期肝硬化患者之间MTT和PS的总体差异具有统计学意义（分别为P = 0.010和P = 0.002）。三组的MTT值分别为15.613±4.1746秒、12.592±4.7518秒和11.721±4.5681秒，而PS分别为18.945±7.2347 mL/min每100 mL、22.767±8.3936 mL/min每100 mL和28.735±13.0654 mL/min每100 mL。失代偿期肝硬化患者的MTT与对照组相比显著降低（P = 0.017），而PS值则显著升高（P = 0.001）。
灌注CT可对肝硬化患者的肝脏微血管变化进行定量评估。灌注CT测量的肝脏微血管参数（MTT和PS）在失代偿期肝硬化中发生了显著改变。
