CT灌注对肝细胞癌和肝转移瘤的定量表征
Quantitative characterization of hepatocellular carcinoma and metastatic liver tumor by CT perfusion.
作者信息
Hayano Koichi, Desai Gaurav S, Kambadakone Avinash R, Fuentes Jorge M, Tanabe Kenneth K, Sahani Dushyant V
机构信息
Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
出版信息
Cancer Imaging. 2013 Dec 11;13(4):512-9. doi: 10.1102/1470-7330.2013.0040.
PURPOSE
To evaluate the diagnostic value of computed tomography perfusion (CTP) in the distinction of hepatocellular carcinomas (HCCs) from metastatic liver tumors.
MATERIALS AND METHODS
CTP data from 90 liver tumors (HCC 38, metastasis 52) in 31 patients (16 men and 15 women; mean age 60.3 years) were studied. CTP was performed on a 16/64 multidetector-row CT scanner using a 30-s duration cine acquisition after rapid bolus injection (5-7 ml/s) of 50-70 ml of iodinated contrast medium. The CTP data were analyzed using a deconvolution model. Metastatic tumors were grouped into hypovascular (n = 36) and hypervascular (n = 16) tumors.
RESULTS AND CONCLUSION
The hypovascular metastases showed a significantly lower blood flow (BF) and blood volume (BV), and higher mean transit time (MTT) than HCC (all P < 0.0001). BF, BV, and MTT of HCCs were substantially lower than those of hypervascular metastases (P = 0.02, P < 0.0001, P = 0.03, respectively). A receiver-operating characteristic analysis showed that BV was a useful marker to distinguish HCCs from hypervascular metastases.
目的
评估计算机断层扫描灌注成像（CTP）在鉴别肝细胞癌（HCC）与肝转移瘤中的诊断价值。
材料与方法
研究了31例患者（16例男性和15例女性；平均年龄60.3岁）的90个肝肿瘤（38个HCC，52个转移瘤）的CTP数据。使用16/64排多层螺旋CT扫描仪，在快速团注（5 - 7 ml/s）50 - 70 ml碘造影剂后，进行30秒的电影采集来进行CTP检查。采用去卷积模型分析CTP数据。将转移瘤分为少血供（n = 36）和多血供（n = 16）肿瘤。
结果与结论
少血供转移瘤的血流（BF）和血容量（BV）显著低于HCC，平均通过时间（MTT）高于HCC（均P < 0.0001）。HCC的BF、BV和MTT显著低于多血供转移瘤（分别为P = 0.02、P < 0.0001、P = 0.03）。受试者工作特征分析表明，BV是鉴别HCC与多血供转移瘤的有用指标。
Zotero 插件