Shteinberg Michal, Weiler-Ravel Daniel, Adir Yochai
Unit of Pulmonary Medicine, Carmel Medical Center, Haifa, Israel.
Harefuah. 2009 May;148(5):333-6, 348.
Overlap syndrome is a term which specifies the existence of both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) in the same patient. The prevalence of OSA in COPD patients equals its prevalence in the general population. Overlap patients have a greater degree of hypoxemia and hypercapnea than COPD patients matched for stage. They also have a greater prevalence of pulmonary hypertension and right heart failure, and suffer higher morbidity. Due to these consequences of the overlap syndrome, it is recommended to actively search for its existence in COPD patients, and to treat it with continuous positive airway pressure (CPAP) concurrently with oxygen and optimal pharmacological treatment of COPD.
重叠综合征是指同一患者同时存在慢性阻塞性肺疾病（COPD）和阻塞性睡眠呼吸暂停（OSA）的一种病症。COPD患者中OSA的患病率与普通人群中的患病率相当。与同阶段的COPD患者相比，重叠综合征患者的低氧血症和高碳酸血症程度更严重。他们患肺动脉高压和右心衰竭的几率也更高，且发病率更高。鉴于重叠综合征的这些后果，建议积极筛查COPD患者中是否存在该综合征，并采用持续气道正压通气（CPAP）进行治疗，同时给予吸氧以及对COPD进行最佳药物治疗。
