桑叶提取物对体内外脂质代谢平衡的影响。
Effects of mulberry (Morus alba L.) extracts on lipid homeostasis in vitro and in vivo.
机构信息
Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.
出版信息
J Agric Food Chem. 2009 Aug 26;57(16):7605-11. doi: 10.1021/jf9014697.
The objective of this study was to investigate the lipid-lowering effects of mulberry water extracts (MWEs). To evaluate the hypolipidemic effect of MWEs, hamsters were fed with either high fat/cholesterol diets (HFCD) or HFCD supplemented with 1 and 2% MWEs for 12 weeks. Plasma total cholesterol (TC) and triglyceride (TG) levels of hamsters fed HFCD with MWEs were significantly reduced by about 30-37% and 16-35%, respectively, as compared to those without MWEs. Similar results were also measured in hepatic TC and TG of hamsters fed HFCD with MWEs. Low-density lipoprotein receptor (LDLR) gene expression and the uptake ability of low-density lipoprotein (LDL) in HepG2 cells were also upregulated by additions of MWEs. MWEs also decreased the gene expressions of enzymes involved in the TG and TC biosyntheses. Results suggest that hypolipidemic effects of MWEs are via an enhancement of LDLR gene expression and the clearance ability of LDL and a decrease in the lipid biosynthesis. Therefore, MWEs could be used as a natural agent against hyperlipidemia.
本研究旨在探讨桑椹水提取物（MWEs）的降脂作用。为了评估 MWEs 的降血脂作用，将仓鼠用高脂肪/胆固醇饮食（HFCD）或补充 1%和 2%MWEs 的 HFCD 喂养 12 周。与未添加 MWEs 的 HFCD 组相比，用 MWEs 喂养的 HFCD 组的仓鼠血浆总胆固醇（TC）和甘油三酯（TG）水平分别降低了约 30-37%和 16-35%。在喂食 HFCD 加 MWEs 的仓鼠的肝 TC 和 TG 中也测量到了类似的结果。MWEs 的添加还上调了低密度脂蛋白受体（LDLR）基因表达和 HepG2 细胞中低密度脂蛋白（LDL）的摄取能力。MWEs 还降低了参与 TG 和 TC 生物合成的酶的基因表达。结果表明，MWEs 的降脂作用是通过增强 LDLR 基因表达和 LDL 的清除能力以及降低脂质生物合成来实现的。因此，MWEs 可以用作治疗高血脂的天然药物。
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