Aghdam Masoud Akbari, Pagán Ana, García-Estañ Joaquín, Atucha Noemí M
Departamento Fisiología, Facultad Medicina, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, 30120 Murcia, Spain.
Nutrients. 2024 Dec 27;17(1):49. doi: 10.3390/nu17010049.
Numerous epidemiological studies have demonstrated that consuming foods rich in polyphenols and flavonoids can have beneficial effects on various diseases, including arterial hypertension (HTN). Recent research from our laboratory has shown that certain flavonoids exhibit antihypertensive properties in several animal models of HTN. Our objective was to evaluate the effect of L. (white mulberry) extracts in an experimental HTN model characterized by nitric oxide (NO) deficiency.
Male Sprague-Dawley rats were divided into four groups: a control group, hypertensive rats treated with an NO synthesis inhibitor (L-NAME) in drinking water for six weeks, L-NAME rats treated with L. extract, and L-NAME rats treated simultaneously with captopril. After six weeks of treatment, we measured blood pressure, endothelial vascular function in the aorta, and platelet aggregation function.
L. extract partially prevented the development of arterial hypertension due to NO deficiency, although it did not completely normalize blood pressure as captopril did. The extract reduced the excessive vasoconstrictor response to phenylephrine in aortic rings and improved vasodilation in response to acetylcholine, with both effects dependent on increased NO production. L. extract also reduced the increased platelet aggregation in response to ADP and collagen in hypertensive animals, although it did not fully normalize this function.
L. extract demonstrates antihypertensive effects, improves vascular reactivity, and reduces platelet aggregation in a model of arterial hypertension. These effects are primarily related to an increase in nitric oxide activity.
众多流行病学研究表明，食用富含多酚和黄酮类化合物的食物对包括动脉高血压（HTN）在内的各种疾病可能具有有益作用。我们实验室最近的研究表明，某些黄酮类化合物在几种高血压动物模型中具有降压特性。我们的目的是评估白桑提取物在以一氧化氮（NO）缺乏为特征的实验性高血压模型中的作用。
将雄性Sprague-Dawley大鼠分为四组：对照组、饮用含NO合成抑制剂（L-NAME）的水六周的高血压大鼠、用白桑提取物治疗的L-NAME大鼠，以及同时用卡托普利治疗的L-NAME大鼠。治疗六周后，我们测量了血压、主动脉的内皮血管功能和血小板聚集功能。
白桑提取物部分预防了因NO缺乏导致的动脉高血压的发展，尽管它没有像卡托普利那样使血压完全恢复正常。该提取物降低了主动脉环对去氧肾上腺素的过度血管收缩反应，并改善了对乙酰胆碱的血管舒张反应，这两种作用均依赖于NO生成的增加。白桑提取物还降低了高血压动物对ADP和胶原蛋白的血小板聚集增加，尽管它没有使该功能完全恢复正常。
白桑提取物在动脉高血压模型中显示出降压作用，改善血管反应性并降低血小板聚集。这些作用主要与一氧化氮活性增加有关。
