血清素的扩展生物学
The expanded biology of serotonin.
作者信息
Berger Miles, Gray John A, Roth Bryan L
机构信息
Department of Psychiatry, University of California, San Francisco, California 94143, USA.
出版信息
Annu Rev Med. 2009;60:355-66. doi: 10.1146/annurev.med.60.042307.110802.
Abstract
Serotonin is perhaps best known as a neurotransmitter that modulates neural activity and a wide range of neuropsychological processes, and drugs that target serotonin receptors are used widely in psychiatry and neurology. However, most serotonin is found outside the central nervous system, and virtually all of the 15 serotonin receptors are expressed outside as well as within the brain. Serotonin regulates numerous biological processes including cardiovascular function, bowel motility, ejaculatory latency, and bladder control. Additionally, new work suggests that serotonin may regulate some processes, including platelet aggregation, by receptor-independent, transglutaminase-dependent covalent linkage to cellular proteins. We review this new "expanded serotonin biology" and discuss how drugs targeting specific serotonin receptors are beginning to help treat a wide range of diseases.
摘要
血清素或许最为人所知的是作为一种调节神经活动和广泛神经心理过程的神经递质，并且靶向血清素受体的药物在精神病学和神经病学中被广泛使用。然而，大多数血清素存在于中枢神经系统之外，实际上15种血清素受体中的所有受体在脑外以及脑内均有表达。血清素调节众多生物学过程，包括心血管功能、肠道蠕动、射精潜伏期和膀胱控制。此外，新的研究表明，血清素可能通过与细胞蛋白的受体非依赖性、转谷氨酰胺酶依赖性共价连接来调节某些过程，包括血小板聚集。我们综述了这种新的“扩展的血清素生物学”，并讨论了靶向特定血清素受体的药物如何开始有助于治疗多种疾病。
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