Sudhakaran Gokul, Chakraborty Shreya, Kumar Ashok, Bharti S Ankit Kumar, Csaba Vágvölgyi, Valan Arasu M, Namasivayam S Karthick Raja, Arockiaraj Jesu
Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, 602117, India.
Toxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Tamil Nadu, 603203, India.
Curr Microbiol. 2025 Jul 15;82(9):386. doi: 10.1007/s00284-025-04379-8.
Psilocybe species, commonly known as "magic mushrooms", are a group of hallucinogenic fungi known for their psychoactive compounds such as psilocybin, psilocin, baeocystin, and norbaeocystin. These species have been the focus of scientific study due to their potential therapeutic applications, despite their classification as controlled substances in many jurisdictions. This review aims to provide a comprehensive overview of various Psilocybe mushrooms, highlighting their chemical compositions, genetic diversity, and therapeutic potential, particularly in the treatment of mental health conditions such as depression, anxiety, PTSD, addiction, and cluster headaches. By reviewing existing scientific literature, this review examines the pharmacological effects and therapeutic applications of Psilocybe mushrooms. The review includes novel contributions such as the identification of alternative pathways for psilocybin synthesis and taxonomic consolidations among Psilocybe species. It also explores the cultural context and traditional uses of these mushrooms. The findings indicate that Psilocybe mushrooms exhibit significant potential for therapeutic use in mental health treatment. The review also underscores the importance of ongoing research into the pharmacological properties of these mushrooms to better understand their effects and potential benefits. Despite their current legal status, Psilocybe mushrooms hold considerable promise for future therapeutic applications. There is a need for further investigation to fully explore their potential in medical and cultural contexts. This review sets a foundation for future research and drug development endeavors, advocating for a more nuanced understanding of these complex biological entities.
裸盖菇属物种，通常被称为“神奇蘑菇”，是一类致幻真菌，因其含有如裸盖菇素、脱磷酸裸盖菇素、巴氏丝裂霉素和去甲巴氏丝裂霉素等精神活性化合物而闻名。尽管在许多司法管辖区它们被归类为管制物质，但由于其潜在的治疗应用，这些物种一直是科学研究的重点。本综述旨在全面概述各种裸盖菇，强调它们的化学成分、遗传多样性和治疗潜力，特别是在治疗抑郁症、焦虑症、创伤后应激障碍、成瘾和丛集性头痛等心理健康状况方面。通过回顾现有科学文献，本综述研究了裸盖菇的药理作用和治疗应用。该综述包括一些新的贡献，如确定裸盖菇素合成的替代途径以及裸盖菇属物种之间的分类学整合。它还探讨了这些蘑菇的文化背景和传统用途。研究结果表明，裸盖菇在心理健康治疗中具有显著的治疗潜力。该综述还强调了持续研究这些蘑菇药理特性的重要性，以便更好地了解它们的作用和潜在益处。尽管它们目前的法律地位如此，但裸盖菇在未来治疗应用方面仍有很大前景。需要进一步研究以充分探索它们在医学和文化背景中的潜力。本综述为未来的研究和药物开发努力奠定了基础，倡导对这些复杂生物实体有更细致入微的理解。
