Bussing R, Levin G M
J Child Adolesc Psychopharmacol. 1993 Spring;3(1):53-8. doi: 10.1089/cap.1993.3.53.
ABSTRACT An 11-year-old child with obsessive-compulsive disorder, major depression, and attentiondeficit hyperactivity disorder was successfully treated with a combination of fluoxetine (mean 30 mg daily) and methamphetamine (sustained release 10 mg daily). Methamphetamine was selected because of the desirability of avoiding stimulants whose commercial formulations contain food dyes (this child appeared sensitive to tartrazine in dextroamphetamine and other agents), whose effects on hepatic metabolism were minimal (unlike methylphenidate) and whose mechanism of action is reliably rapid (unlike pemoline). Although methamphetamine carries the stigma of an abusable drug and has been implicated in neurotoxicity in animals when used at extremely high doses, methamphetamine may have certain advantages over other psychostimulants in some clinical situations. The combined use of fluoxetine and methamphetamine did not appear to be associated with significant adverse effects.
摘要 一名患有强迫症、重度抑郁症和注意力缺陷多动障碍的11岁儿童，通过氟西汀（平均每日30毫克）和甲基苯丙胺（缓释片，每日10毫克）联合治疗取得成功。选择甲基苯丙胺是因为希望避免使用其商业制剂含有食用色素的兴奋剂（该儿童似乎对右旋苯丙胺和其他药物中的酒石黄敏感），其对肝脏代谢的影响最小（与哌甲酯不同），且其作用机制起效可靠迅速（与匹莫林不同）。尽管甲基苯丙胺背负着可滥用药物的恶名，且在极高剂量使用时已被证明会对动物产生神经毒性，但在某些临床情况下，甲基苯丙胺可能比其他精神兴奋剂具有某些优势。氟西汀和甲基苯丙胺联合使用似乎未产生明显不良反应。
