Williamson Lauren L, Cheng Ruey-Kuang, Etchegaray Mikel, Meck Warren H
Department of Psychology and Neuroscience, Duke University, Durham, North Carolina 27708, USA.
Curr Drug Abuse Rev. 2008 Jun;1(2):203-12. doi: 10.2174/1874473710801020203.
The indirect dopamine (DA) agonist methamphetamine (MAP) is evaluated in terms of its impact on the speed of temporal processing across multiple time scales involving both interval and circadian timing. Behavioral and neuropharmacological aspects of drug abuse, habit formation, neurotoxicity, and the potential links between interval and circadian timing are reviewed. The view that emerges is one in which the full spectrum of MAP-induced effects on timing and time perception is both complex and dynamic in as much as it involves DA-glutamate interactions and gene expression within cortico-striatal circuitry spanning oscillation periods ranging from milliseconds to multiple hours. The conclusion is that the psychostimulant properties of MAP are very much embedded within the context of temporal prediction and the anticipation of reward.
间接多巴胺（DA）激动剂甲基苯丙胺（MAP）根据其对涉及间隔和昼夜节律定时的多个时间尺度上的时间处理速度的影响进行评估。本文综述了药物滥用、习惯形成、神经毒性的行为和神经药理学方面，以及间隔和昼夜节律定时之间的潜在联系。由此形成的观点是，MAP对定时和时间感知的全面影响是复杂且动态的，因为它涉及多巴胺-谷氨酸相互作用以及跨越从毫秒到数小时振荡周期的皮质-纹状体回路中的基因表达。结论是，MAP的精神刺激特性在很大程度上嵌入在时间预测和奖励预期的背景中。
