Sessa W C
Yale University School of Medicine, Vascular Biology & Therapeutic Program, New Haven, CT 06520, USA.
J Thromb Haemost. 2009 Jul;7 Suppl 1:35-7. doi: 10.1111/j.1538-7836.2009.03424.x.
In the past decade, the importance of the vascular endothelium as a multifunctional regulator of vascular smooth muscle physiology and pathophysiology has been appreciated. Indeed, the endothelium responds to hemodynamic stimuli (pressure, shear stress and wall strain) and locally manufactured mediators (such as bradykinin, prostaglandins, angiotensin II and nitric oxide) that can influence blood flow, cell trafficking into tissue and angiogenesis. In this chapter, the importance of nitric oxide (NO) as a mediator of blood flow control, vascular permeability and angiogenesis will be discussed.
在过去十年中，血管内皮作为血管平滑肌生理和病理生理的多功能调节因子的重要性已得到认可。事实上，内皮对血流动力学刺激（压力、剪切应力和壁应变）以及局部产生的介质（如缓激肽、前列腺素、血管紧张素II和一氧化氮）作出反应，这些介质可影响血流、细胞向组织内的迁移以及血管生成。在本章中，将讨论一氧化氮（NO）作为血流控制、血管通透性和血管生成介质的重要性。
