Murohara Toyoaki, Asahara Takayuki
Department of Internal Medicine, Division of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Antioxid Redox Signal. 2002 Oct;4(5):825-31. doi: 10.1089/152308602760598981.
Ischemic heart disease and peripheral artery disease mainly develop as a consequence of atherosclerotic lesion formation. Angiogenesis, the formation of new blood vessels from the preexisting vascular bed, is of paramount importance in the maintenance of vascular integrity both in the repair process of damaged tissue (wound healing) and in the formation of collateral vessels in response to tissue ischemia. Angiogenesis is a complex process that is orchestrated by a multitude of cytokines/chemokines and growth factors. In its broadest sense, angiogenesis cannot be viewed as a single process. It is likely that different mediators are involved in different phases of angiogenesis. Vascular endothelial cells produce nitric oxide (NO), an endothelium-derived labile molecule, which maintains vascular homeostasis and thereby prevents vascular atherosclerotic changes. In patients with ischemic heart disease and peripheral artery disease, the release of endothelium-derived NO is decreased, which plays an important role in the atherosclerotic disease progression. In recent years, endothelium-derived NO has been shown to modulate angiogenesis in vitro and in vivo. In this review, we summarize recent progress in the field of the NO-mediated regulation of postnatal angiogenesis.
缺血性心脏病和外周动脉疾病主要是由于动脉粥样硬化病变形成所致。血管生成是指从已有的血管床形成新的血管，在受损组织的修复过程（伤口愈合）以及对组织缺血的反应中形成侧支血管时，对于维持血管完整性至关重要。血管生成是一个复杂的过程，由多种细胞因子/趋化因子和生长因子协调。从最广泛的意义上讲，血管生成不能被视为一个单一的过程。不同的介质可能参与血管生成的不同阶段。血管内皮细胞产生一氧化氮（NO），一种内皮衍生的不稳定分子，它维持血管稳态，从而防止血管发生动脉粥样硬化改变。在缺血性心脏病和外周动脉疾病患者中，内皮衍生的NO释放减少，这在动脉粥样硬化疾病进展中起重要作用。近年来，已证明内皮衍生的NO在体外和体内调节血管生成。在本综述中，我们总结了NO介导的出生后血管生成调节领域的最新进展。
