甲状旁腺激素对成体造血干细胞龛的影响。

The influence of parathyroid hormone on the adult hematopoietic stem cell niche.

作者信息

Rashidi Narges, Adams Gregor B

机构信息

Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at University of Southern California, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

出版信息

Curr Osteoporos Rep. 2009 Jul;7(2):53-7. doi: 10.1007/s11914-009-0010-7.

DOI:10.1007/s11914-009-0010-7

PMID:19631029

Abstract

Adult hematopoietic stem cells (HSCs) reside in the bone marrow in stable microenvironments known as the stem cell niche. One key component of the stem cell niche is cells of the osteoblastic lineage. Factors that are known to affect osteoblast activity, such as parathyroid hormone (PTH), have also been shown to affect the HSCs. Treatment of mice with PTH has led to beneficial effects on the HSC pool, which have led to clinical trials of PTH treatment to enhance HSC-based therapies.

摘要

成体造血干细胞（HSCs）存在于骨髓中被称为干细胞微环境的稳定微环境中。干细胞微环境的一个关键组成部分是成骨细胞谱系的细胞。已知影响成骨细胞活性的因素，如甲状旁腺激素（PTH），也已被证明会影响造血干细胞。用PTH治疗小鼠对造血干细胞池产生了有益影响，这导致了PTH治疗增强基于造血干细胞疗法的临床试验。