Mansour Wejdene, Poirel Laurent, Bettaieb Dalia, Bouallegue Olfa, Boujaafar Noureddine, Nordmann Patrice
Service de Bactériologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris Paris-Sud, 94275 K.-Bicêtre, France.
Diagn Microbiol Infect Dis. 2009 Aug;64(4):458-61. doi: 10.1016/j.diagmicrobio.2009.04.003.
This study was conducted to identify metallo-beta-lactamase (MBL) producers among a collection of 75 nonrepetitive carbapenem-resistant Pseudomonas aeruginosa isolates recovered between November 2003 and May 2007 at the University Hospital Sahloul, Sousse, Tunisia. Five isolates produced the MBL VIM-2. Those bla(VIM-2)-positive isolates were clonally related according to pulsed-field gel electrophoresis analysis. This carbapenemase was very likely chromosomally located and as a form of a gene cassette in a class 1 integron. This is the 1st report of spread of VIM-2 producers in Tunisia.
本研究旨在从2003年11月至2007年5月在突尼斯苏塞市萨赫勒大学医院分离出的75株非重复性耐碳青霉烯铜绿假单胞菌中鉴定金属β-内酰胺酶（MBL）产生菌。5株分离菌产生MBL VIM-2。根据脉冲场凝胶电泳分析，那些bla(VIM-2)阳性分离菌具有克隆相关性。这种碳青霉烯酶很可能位于染色体上，并以基因盒的形式存在于1类整合子中。这是突尼斯VIM-2产生菌传播的首次报道。
