Sigma-2受体在牛乳头瘤病毒相关膀胱肿瘤中的表达。
Sigma-2 receptor expression in bovine papillomavirus-associated urinary bladder tumours.
作者信息
Roperto S, Colabufo N A, Inglese C, Urraro C, Brun R, Mezza E, Staibano S, Raso C, Maiolino P, Russo V, Palma E, Roperto F
机构信息
Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, 80137 Naples, Italy.
出版信息
J Comp Pathol. 2010 Jan;142(1):19-26. doi: 10.1016/j.jcpa.2009.06.001. Epub 2009 Jul 23.
The expression of sigma-2 receptors was investigated in nine urothelial tumours of the urinary bladder of cattle. Each tumour was associated with the presence of DNA of bovine papillomavirus type-2 (BPV-2) and expression of the E5 viral oncoprotein. Five tumours were classified as low-grade carcinoma on the basis of morphological criteria and calculation of mean nuclear area (MNA) and mean nuclear perimeter (MNP). Four tumours were classified as high-grade carcinoma. Sigma-2 receptors were overexpressed in both types of carcinoma. In control normal bovine bladder tissue the density of receptors (expressed as the B(max)) was 0.37 pmol/mg of protein. Low-grade carcinomas had a mean B(max) of 1.37+/-0.32 pmol/mg of protein (range 1.03-1.86) and in high-grade carcinomas the mean B(max) was 10.9+/-2.8 pmol/mg of protein (range 8.2-14). The difference in B(max) between low- and high-grade carcinomas was statistically significant (P=0.0001).
对9例牛膀胱尿路上皮肿瘤中sigma-2受体的表达进行了研究。每例肿瘤均与2型牛乳头瘤病毒（BPV-2）的DNA存在及E5病毒癌蛋白的表达相关。根据形态学标准以及平均核面积（MNA）和平均核周长（MNP）的计算，5例肿瘤被归类为低级别癌。4例肿瘤被归类为高级别癌。sigma-2受体在两种类型的癌中均过度表达。在对照正常牛膀胱组织中，受体密度（以B(max)表示）为0.37 pmol/mg蛋白质。低级别癌的平均B(max)为1.37±0.32 pmol/mg蛋白质（范围为1.03 - 1.86），高级别癌的平均B(max)为10.9±2.8 pmol/mg蛋白质（范围为8.2 - 14）。低级别癌和高级别癌之间B(max)的差异具有统计学意义（P = 0.0001）。
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