Roperto S, Borzacchiello G, Casellato R, Galati P, Russo V, Sonnino S, Roperto F
Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, via Delpino 1, 80137 Naples, Itatly.
J Comp Pathol. 2007 Aug-Oct;137(2-3):87-93. doi: 10.1016/j.jcpa.2007.03.008. Epub 2007 Jul 12.
This study was based on 30 papillomavirus-associated urinary bladder tumours from cattle with chronic haematuria, the animals having been kept since birth on pasture rich in bracken fern. The ganglioside content was assessed and compared with that of normal bovine urinary bladders, which was shown to be 28.6+/-3.3 (mean+/-SD) microg of lipid-bound sialic acid per gram of fresh tissue. In neoplastic bladder samples this value was higher but variable (120.9+/-80.6 in benign tumours, and 94.7+/-45.7 in malignant tumours). The main ganglioside, GM3, represented ca 75% of the total ganglioside mixture in normal tissues and 50-80% in tumour samples. GM1, GM2, GD1a, GD3 and FucGM1 were found as minor components. The study suggested that GM3 ganglioside may have a crucial role in "downregulation" of the metastatic potential of bovine urothelial cancers.
本研究基于30例来自患有慢性血尿的牛的乳头瘤病毒相关膀胱肿瘤，这些动物自出生起就饲养在富含蕨菜的牧场上。评估了神经节苷脂含量，并与正常牛膀胱的神经节苷脂含量进行比较，结果显示正常牛膀胱每克新鲜组织中脂质结合唾液酸含量为28.6±3.3（平均值±标准差）微克。在肿瘤性膀胱样本中，该值较高但存在差异（良性肿瘤中为120.9±80.6，恶性肿瘤中为94.7±45.7）。主要神经节苷脂GM3在正常组织中约占总神经节苷脂混合物的75%，在肿瘤样本中占50 - 80%。GM1、GM2、GD1a、GD3和FucGM1为次要成分。该研究表明，GM3神经节苷脂可能在牛尿路上皮癌转移潜能的“下调”中起关键作用。
