Dougherty Donald M, Mathias Charles W, Marsh-Richard Dawn M, Prevette Kristen N, Dawes Michael A, Hatzis Erin S, Palmes Guy, Nouvion Sylvain O
Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, TX 78229-3900, USA.
Psychiatry Res. 2009 Aug 30;169(1):22-7. doi: 10.1016/j.psychres.2008.06.011. Epub 2009 Jul 23.
This study examined clinical characteristics and laboratory-measured impulsive behavior of adolescents engaging in either non-suicidal self-injury with (NSSI+SA; n=25) or without (NSSI-Only; n=31) suicide attempts. We hypothesized that adolescent with NSSI+SI would exhibit more severe clinical symptoms and higher levels of behavioral impulsivity compared to adolescents with NSSI-Only. Adolescents were recruited from an inpatient psychiatric hospital unit and the two groups were compared on demographic characteristics, psychopathology, self-reported clinical ratings, methods of non-suicidal self-injury, and two laboratory impulsivity measures. Primary evaluations were conducted during psychiatric hospitalization, and a subset of those tested during hospitalization was retested 4-6 weeks after discharge. During hospitalization, NSSI+SA patients reported worse depression, hopelessness, and impulsivity on standard clinical measures, and demonstrated elevated impulsivity on a reward-directed laboratory measure compared to NSSI-Only patients. In the follow-up analyses, depression, hopelessness, suicidal ideation, and laboratory impulsivity were improved for both groups, but the NSSI+SA group still exhibited significantly more depressive symptoms, hopelessness, and impulsivity than the NSSI-Only group. Risk assessments for adolescents with NSSI+SA should include consideration not only of the severity of clinical symptoms but of the current level impulsivity as well.
本研究调查了有自杀未遂(NSSI+SA;n=25)和无自杀未遂(仅NSSI;n=31)的青少年非自杀性自伤行为的临床特征和实验室测量的冲动行为。我们假设,与仅患有NSSI的青少年相比,患有NSSI+SA的青少年会表现出更严重的临床症状和更高水平的行为冲动性。青少年从一家住院精神科病房招募,对两组在人口统计学特征、精神病理学、自我报告的临床评分、非自杀性自伤方法以及两项实验室冲动性测量方面进行比较。主要评估在精神科住院期间进行,住院期间接受测试的一部分人在出院后4-6周进行重新测试。住院期间,与仅NSSI的患者相比,NSSI+SA患者在标准临床测量中报告的抑郁、绝望和冲动情况更严重,并且在一项奖励导向的实验室测量中表现出更高的冲动性。在后续分析中,两组的抑郁、绝望、自杀意念和实验室冲动性都有所改善,但NSSI+SA组仍然比仅NSSI组表现出明显更多的抑郁症状、绝望和冲动性。对患有NSSI+SA的青少年进行风险评估时,不仅应考虑临床症状的严重程度,还应考虑当前的冲动水平。