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Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease.

作者信息

Fernandes Karla S S, Brum Doralina Guimaraes, Sandrim Valeria Cristina, Guerreiro Carlos Tostes, Barreira Amilton Antunes, Tanus-Santos José Eduardo

机构信息

Department of Pharmacology, Medicine and Rehabilitation of the Locomotor Apparatus, Medical School of Ribeirão Preto, University of São Paulo, 14049-900, Ribeirão Preto, SP, Brazil.

出版信息

J Neuroimmunol. 2009 Sep 29;214(1-2):128-31. doi: 10.1016/j.jneuroim.2009.07.004. Epub 2009 Jul 24.

DOI:10.1016/j.jneuroim.2009.07.004
PMID:19631393
Abstract

Multiple sclerosis (MS) is an autoimmune disease causing severe neurological disability. This study was carried out in order to determine whether the MMP-9 C(-1562)T and (CA)(13-25) polymorphisms are associated with MS. A total of 165 patients (92 whites/73 mulattos) and 191 controls (96 whites/95 mulattos) were enrolled in the study. While no difference in C(-1562)T polymorphism was observed between MS and healthy subjects, (CA)(n) genotypes and alleles were associated with MS. Moreover, the haplotypes are not associated with MS but seem to be relevant to the clinical status of MS. Thus the (CA)(n) polymorphism may contribute to MS susceptibility, but C(-1562)T and (CA)(n) haplotypes may modulate disease severity.

摘要

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