Cameron Elizabeth M, Spencer Sade, Lazarini Jonathan, Harp Christopher T, Ward E Sally, Burgoon Mark, Owens Gregory P, Racke Michael K, Bennett Jeffrey L, Frohman Elliot M, Monson Nancy L
Department of Neurology, University of Texas Southwestern Medical Center, Dallas TX 75154, USA.
J Neuroimmunol. 2009 Aug 18;213(1-2):123-30. doi: 10.1016/j.jneuroim.2009.05.014. Epub 2009 Jul 24.
We identified a unique antibody gene mutation pattern (i.e. "signature") in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91% accuracy in a small cohort of clinically isolated syndrome patients. If confirmed, signature prevalence would be a novel genetic diagnostic tool candidate for patients with early demyelinating disease of the central nervous system.
我们在多发性硬化症（MS）患者的脑脊液（CSF）B细胞中发现了一种独特的抗体基因突变模式（即“特征”），而对照组人群中不存在这种模式。在一小群临床孤立综合征患者中，处于发展为MS风险的患者脑脊液B细胞中该特征的流行率以91%的准确率预测了向MS的转化。如果得到证实，特征流行率将成为中枢神经系统早期脱髓鞘疾病患者一种新型的基因诊断工具候选物。
