一种独特抗体基因特征预测向临床确诊多发性硬化症转化的潜力。
Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis.
作者信息
Cameron Elizabeth M, Spencer Sade, Lazarini Jonathan, Harp Christopher T, Ward E Sally, Burgoon Mark, Owens Gregory P, Racke Michael K, Bennett Jeffrey L, Frohman Elliot M, Monson Nancy L
机构信息
Department of Neurology, University of Texas Southwestern Medical Center, Dallas TX 75154, USA.
出版信息
J Neuroimmunol. 2009 Aug 18;213(1-2):123-30. doi: 10.1016/j.jneuroim.2009.05.014. Epub 2009 Jul 24.
Abstract
We identified a unique antibody gene mutation pattern (i.e. "signature") in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91% accuracy in a small cohort of clinically isolated syndrome patients. If confirmed, signature prevalence would be a novel genetic diagnostic tool candidate for patients with early demyelinating disease of the central nervous system.
摘要
我们在多发性硬化症（MS）患者的脑脊液（CSF）B细胞中发现了一种独特的抗体基因突变模式（即“特征”），而对照组人群中不存在这种模式。在一小群临床孤立综合征患者中，处于发展为MS风险的患者脑脊液B细胞中该特征的流行率以91%的准确率预测了向MS的转化。如果得到证实，特征流行率将成为中枢神经系统早期脱髓鞘疾病患者一种新型的基因诊断工具候选物。
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本文引用的文献
1
The prognostic significance of cerebrospinal fluid in multiple sclerosis.脑脊液在多发性硬化症中的预后意义。
J Neurol Sci. 2009 Apr 15;279(1-2):21-5. doi: 10.1016/j.jns.2008.12.029. Epub 2009 Jan 31.
2
Winning combination: the additive/synergistic benefits of IVIg in corticosteroid refractory optic neuritis.成功组合：静脉注射免疫球蛋白在皮质类固醇难治性视神经炎中的附加/协同益处。
Eur J Neurol. 2008 Nov;15(11):1145. doi: 10.1111/j.1468-1331.2008.02257.x.
3
Quantitative estimation of the albumin and gamma globulin in normal and pathologic cerebrospinal fluid by immunochemical methods.通过免疫化学方法对正常和病理性脑脊液中的白蛋白和γ球蛋白进行定量估计。
Am J Med. 1948 May;4(5):653-62. doi: 10.1016/s0002-9343(48)90389-1.
4
B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases.B细胞和自身抗体在多发性硬化症及相关炎性脱髓鞘疾病发病机制中的作用
Adv Immunol. 2008;98:121-49. doi: 10.1016/S0065-2776(08)00404-5.
5
Treatment of corticosteroid refractory optic neuritis in multiple sclerosis patients with intravenous immunoglobulin.静脉注射免疫球蛋白治疗多发性硬化症患者的皮质类固醇难治性视神经炎。
Eur J Neurol. 2008 Nov;15(11):1163-7. doi: 10.1111/j.1468-1331.2008.02258.x. Epub 2008 Aug 21.
6
B cells and multiple sclerosis.B细胞与多发性硬化症
Lancet Neurol. 2008 Sep;7(9):852-8. doi: 10.1016/S1474-4422(08)70192-3.
7
Rituximab induces clinical stabilization in a patient with fulminant multiple sclerosis not responding to natalizumab. Evidence for disease heterogeneity.利妥昔单抗使一名对那他珠单抗无反应的暴发性多发性硬化患者的病情实现临床稳定。疾病异质性的证据。
J Neurol. 2008 Sep;255(9):1436-8. doi: 10.1007/s00415-008-0956-x. Epub 2008 Jul 17.
8
CSF IgG heavy-chain bias in patients at the time of a clinically isolated syndrome.临床孤立综合征患者脑脊液中IgG重链偏向性
J Neuroimmunol. 2008 Aug 13;199(1-2):126-32. doi: 10.1016/j.jneuroim.2008.04.031. Epub 2008 Jun 10.
9
B-cell depletion with rituximab in relapsing-remitting multiple sclerosis.利妥昔单抗治疗复发缓解型多发性硬化症中的B细胞清除
N Engl J Med. 2008 Feb 14;358(7):676-88. doi: 10.1056/NEJMoa0706383.
10
Pharmacological treatment of early multiple sclerosis.早期多发性硬化症的药物治疗
Drugs. 2008;68(1):73-83. doi: 10.2165/00003495-200868010-00005.
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