Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE, Canada.
Behav Brain Res. 2009 Dec 28;205(2):564-7. doi: 10.1016/j.bbr.2009.07.018. Epub 2009 Jul 23.
One hallmark of neurological dysfunction is a reduction in paradoxical sleep (PS) time. To determine if adult rats treated neonatally with low dose domoic acid have altered sleep patterns, a home cage analysis of electroencephalogram (EEG) waveforms was performed using radio telemetry. Domoate treated rats spent significantly less time in PS than controls during daytime hours even though they spent the same total amount of time sleeping, and showed no difference in stage shifts into the PS stage.
神经功能障碍的一个标志是异相睡眠（PS）时间减少。为了确定新生期接受低剂量 Domoic 酸治疗的成年大鼠是否有睡眠模式改变，使用无线电遥测术对脑电图（EEG）波形进行了笼内分析。尽管 Domoate 处理的大鼠睡眠时间与对照组相同，但在白天 PS 时间明显减少，并且在 PS 阶段的阶段转换中没有差异。
