脂联素相关基因单核苷酸多态性与汉族2型糖尿病的关联研究
Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese.
作者信息
Wang Yabing, Zhang Di, Liu Yun, Yang Yifeng, Zhao Teng, Xu Jie, Li Sheng, Zhang Zuofeng, Feng Guoyin, He Lin, Xu He
机构信息
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
出版信息
J Genet Genomics. 2009 Jul;36(7):417-23. doi: 10.1016/S1673-8527(08)60131-9.
Single-nucleotide polymorphisms (SNPs) of ADIPOQ, ADIPOR1, and ADIPOR2 have been associated with type 2 diabetes mellitus (T2DM), but there are many conflicting results especially in Chinese populations. To investigate the contribution of the adiponectin genes and their receptors to T2DM, a case-control study was performed and 11 SNPs of ADIPOQ, ADIPOR1, and ADIPOR2 were genotyped in 985 T2DM and 1,050 control subjects. rs16861194 (-11426 A>G) in the putative promoter of ADIPOQ was associated with T2DM (P = 0.007; OR = 1.29, 95%CI 1.08-1.55). None of the other 10 SNPs were associated with T2DM in this study, although rs2241766 and rs1501299 were reported to be associated with T2DM in previous Chinese studies. There was also no significant difference found from the ADIPOQ haplotype analysis, which contains rs16861194. In addition, we also assessed potential gene-gene interactions in three genes and no interactions were found. In conclusion, our results supported the ADIPOQ gene as a possible risk factor for type 2 diabetes in Han Chinese population.
脂联素（ADIPOQ）、脂联素受体1（ADIPOR1）和脂联素受体2（ADIPOR2）的单核苷酸多态性（SNP）与2型糖尿病（T2DM）相关，但存在许多相互矛盾的结果，尤其是在中国人群中。为了研究脂联素基因及其受体对T2DM的影响，我们进行了一项病例对照研究，对985例T2DM患者和1050例对照者的ADIPOQ、ADIPOR1和ADIPOR2的11个SNP进行了基因分型。ADIPOQ推定启动子中的rs16861194（-11426 A>G）与T2DM相关（P = 0.007；OR = 1.29，95%CI 1.08 - 1.55）。本研究中其他10个SNP均与T2DM无关，尽管在之前的中国研究中rs2241766和rs1501299被报道与T2DM相关。包含rs16861194的ADIPOQ单倍型分析也未发现显著差异。此外，我们还评估了这三个基因之间潜在的基因-基因相互作用，未发现相互作用。总之，我们的结果支持ADIPOQ基因可能是中国汉族人群2型糖尿病的一个危险因素。
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